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- W2069080147 abstract "Crumbs polarity complex proteins are essential for cellular and tissue polarity, and for adhesion of epithelial cells. In epithelial tissues deletion of any of three core proteins disrupts localization of the other proteins, indicating structural and functional interdependence among core components. Despite previous studies of function and co-localization that illustrated the properties that these proteins share, it is not known whether an individual component of the complex plays a distinct role in a unique cellular and developmental context. In order to investigate this question, we primarily used confocal imaging to determine the expression and subcellular localization of the core Crumbs polarity complex proteins during ocular development. Here we show that in developing ocular tissues core Crumbs polarity complex proteins, Crb, Pals1 and Patj, generally appear in an overlapping pattern with some exceptions. All three core complex proteins localize to the apical junction of the retinal and lens epithelia. Pals1 is also localized in the Golgi of the retinal cells and Patj localizes to the nuclei of the apically located subset of progenitor cells. These findings suggest that core Crumbs polarity complex proteins exert common and independent functions depending on cellular context." @default.
- W2069080147 created "2016-06-24" @default.
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- W2069080147 date "2015-01-01" @default.
- W2069080147 modified "2023-10-17" @default.
- W2069080147 title "Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye" @default.
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- W2069080147 doi "https://doi.org/10.1016/j.gep.2015.01.002" @default.
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