FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069098706> ?p ?o ?g. }

• W2069098706 endingPage "798" @default.
• W2069098706 startingPage "791" @default.
• W2069098706 abstract "The permeability barrier is mediated by a mixture of ceramides, sterols, and free fatty acids arranged as extracellular lamellar bilayers in the stratum corneum. Whereas prior studies have shown that cholesterol and ceramides are required for normal barrier function, definitive evidence for the importance of nonessential fatty acids is not available. To determine whether epidermal fatty acid synthesis also is required for barrier homeostasis, we applied 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA), an inhibitor of acetyl CoA carboxylase, after disruption of the barrier by acetone or tape stripping. TOFA inhibits epidermal fatty acid by approximately 50% and significantly delays barrier recovery. Moreover, coadministration of palmitate with TOFA normalizes barrier recovery, indicating that the delay is due to a deficiency in bulk fatty acids. Furthermore, TOFA treatment also delays the return of lipids to the stratum corneum and results in abnormalities in the structure of lamellar bodies, the organelle which delivers lipid to the stratum corneum. In addition, the organization of secreted lamellar body material into lamellar bilayers within the stratum corneum interstices is disrupted by TOFA treatment. Finally, these abnormalities in lamellar body and stratum corneum membrane structure are corrected by coapplication of palmitate with TOFA. These results demonstrate a requirement for bulk fatty acids in barrier homeostasis. Thus, inhibiting the epidermal synthesis of any of the three key lipids that form the extracellular, lipid-enriched membranes of the stratum corneum results in an impairment in barrier homeostasis." @default.
• W2069098706 created "2016-06-24" @default.
• W2069098706 creator A5050608918 @default.
• W2069098706 creator A5051847291 @default.
• W2069098706 creator A5082650655 @default.
• W2069098706 date "1993-08-01" @default.
• W2069098706 modified "2023-10-13" @default.
• W2069098706 title "Fatty acids are required for epidermal permeability barrier function." @default.
• W2069098706 cites W128536076 @default.
• W2069098706 cites W158357680 @default.
• W2069098706 cites W1796779887 @default.
• W2069098706 cites W1987203691 @default.
• W2069098706 cites W1994096971 @default.
• W2069098706 cites W2000819908 @default.
• W2069098706 cites W2023702032 @default.
• W2069098706 cites W2024562547 @default.
• W2069098706 cites W2035660063 @default.
• W2069098706 cites W2045883801 @default.
• W2069098706 cites W2048861627 @default.
• W2069098706 cites W2052810894 @default.
• W2069098706 cites W2059714246 @default.
• W2069098706 cites W2119201362 @default.
• W2069098706 cites W2120030741 @default.
• W2069098706 cites W2125110434 @default.
• W2069098706 cites W2136928072 @default.
• W2069098706 cites W2141390960 @default.
• W2069098706 cites W2267841017 @default.
• W2069098706 cites W2284476116 @default.
• W2069098706 cites W2291735246 @default.
• W2069098706 cites W75618519 @default.
• W2069098706 doi "https://doi.org/10.1172/jci116652" @default.
• W2069098706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/294916" @default.
• W2069098706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8102380" @default.
• W2069098706 hasPublicationYear "1993" @default.
• W2069098706 type Work @default.
• W2069098706 sameAs 2069098706 @default.
• W2069098706 citedByCount "148" @default.
• W2069098706 countsByYear W20690987062012 @default.
• W2069098706 countsByYear W20690987062013 @default.
• W2069098706 countsByYear W20690987062014 @default.
• W2069098706 countsByYear W20690987062015 @default.
• W2069098706 countsByYear W20690987062016 @default.
• W2069098706 countsByYear W20690987062017 @default.
• W2069098706 countsByYear W20690987062018 @default.
• W2069098706 countsByYear W20690987062019 @default.
• W2069098706 countsByYear W20690987062020 @default.
• W2069098706 countsByYear W20690987062021 @default.
• W2069098706 countsByYear W20690987062022 @default.
• W2069098706 crossrefType "journal-article" @default.
• W2069098706 hasAuthorship W2069098706A5050608918 @default.
• W2069098706 hasAuthorship W2069098706A5051847291 @default.
• W2069098706 hasAuthorship W2069098706A5082650655 @default.
• W2069098706 hasBestOaLocation W20690987061 @default.
• W2069098706 hasConcept C12554922 @default.
• W2069098706 hasConcept C145156650 @default.
• W2069098706 hasConcept C185592680 @default.
• W2069098706 hasConcept C190283241 @default.
• W2069098706 hasConcept C2777851122 @default.
• W2069098706 hasConcept C2778370115 @default.
• W2069098706 hasConcept C51911345 @default.
• W2069098706 hasConcept C543025807 @default.
• W2069098706 hasConcept C54355233 @default.
• W2069098706 hasConcept C55493867 @default.
• W2069098706 hasConcept C58226133 @default.
• W2069098706 hasConcept C86803240 @default.
• W2069098706 hasConcept C95150158 @default.
• W2069098706 hasConcept C95444343 @default.
• W2069098706 hasConceptScore W2069098706C12554922 @default.
• W2069098706 hasConceptScore W2069098706C145156650 @default.
• W2069098706 hasConceptScore W2069098706C185592680 @default.
• W2069098706 hasConceptScore W2069098706C190283241 @default.
• W2069098706 hasConceptScore W2069098706C2777851122 @default.
• W2069098706 hasConceptScore W2069098706C2778370115 @default.
• W2069098706 hasConceptScore W2069098706C51911345 @default.
• W2069098706 hasConceptScore W2069098706C543025807 @default.
• W2069098706 hasConceptScore W2069098706C54355233 @default.
• W2069098706 hasConceptScore W2069098706C55493867 @default.
• W2069098706 hasConceptScore W2069098706C58226133 @default.
• W2069098706 hasConceptScore W2069098706C86803240 @default.
• W2069098706 hasConceptScore W2069098706C95150158 @default.
• W2069098706 hasConceptScore W2069098706C95444343 @default.
• W2069098706 hasIssue "2" @default.
• W2069098706 hasLocation W20690987061 @default.
• W2069098706 hasLocation W20690987062 @default.
• W2069098706 hasLocation W20690987063 @default.
• W2069098706 hasLocation W20690987064 @default.
• W2069098706 hasOpenAccess W2069098706 @default.
• W2069098706 hasPrimaryLocation W20690987061 @default.
• W2069098706 hasRelatedWork W187845116 @default.
• W2069098706 hasRelatedWork W1969687658 @default.
• W2069098706 hasRelatedWork W1973649841 @default.
• W2069098706 hasRelatedWork W1993386248 @default.
• W2069098706 hasRelatedWork W1994252498 @default.
• W2069098706 hasRelatedWork W2069098706 @default.
• W2069098706 hasRelatedWork W2324639233 @default.
• W2069098706 hasRelatedWork W2395198674 @default.
• W2069098706 hasRelatedWork W4318947496 @default.
• W2069098706 hasRelatedWork W4322744585 @default.

• next