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• W2069101402 startingPage "29" @default.
• W2069101402 abstract "Younger age groups account for proportionally more mortality in influenza pandemics than in seasonal influenza epidemics. Mechanisms that might explain this include young people suffering from an over-reactive immune system (“cytokine storm”), older people benefiting from cross-immunity from a wider variety of previous influenza infections (“antigenic history”), and lifetime immune responses in all people being shaped by their first influenza A infection (“antigenic imprinting” or “original antigenic sin”). We examined whether these mechanisms can explain age-specific influenza mortality patterns, using the complete database of individual deaths in Canada from 1951 to 1999. The mortality pattern during the 1957 pandemic indicates that antigenic imprinting plays an important role in determining age-specific influenza virulence and that both shift years and major drift years contribute significantly to antigenic imprints. This information should help pandemic planners to identify age groups that might respond differently to novel influenza strains." @default.
• W2069101402 created "2016-06-24" @default.
• W2069101402 creator A5042015617 @default.
• W2069101402 creator A5071611289 @default.
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• W2069101402 date "2011-11-01" @default.
• W2069101402 modified "2023-10-16" @default.
• W2069101402 title "Age-specific mortality risk from pandemic influenza" @default.
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• W2069101402 doi "https://doi.org/10.1016/j.jtbi.2011.08.003" @default.
• W2069101402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21856313" @default.
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