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• W2069113458 abstract "The mode of action of the polyene antibiotic amphotericin B (AmB), the drug of choice for the treatment of systemic fungal infections and visceral leishmaniasis, is still unclear. An increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ), toxic in many cases, has been postulated as a possible lethal mechanism for AmB. Cell permeabilization to ethidium bromide (EB) was used as a criterion of viability. Kinetics of the DNA‐EB fluorescent complex formation was studied in ergosterol‐containing Leishmania promastigotes. Intracellular Ca 2+ concentration was measured using quin‐2 fluorescence in parallel aliquots. It is shown in this work that AmB can act as an efficient Ca 2+ ionophore. However, the rapid permeabilization effect induced by AmB on these cells was not dependent on an increase in [Ca 2+ ] i . On the contrary, it was found that leishmanicidal effect of AmB was enhanced in the absence of external calcium. Furthermore, A23187 a Ca 2+ ionophore did not provoke cell penneabilization to EB." @default.
• W2069113458 created "2016-06-24" @default.
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• W2069113458 date "1990-01-01" @default.
• W2069113458 modified "2023-10-14" @default.
• W2069113458 title "Increased calcium permeability is not responsible for the rapid lethal effects of amphotericin B on<i>Leishmania sp</i>" @default.
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• W2069113458 doi "https://doi.org/10.1016/0014-5793(90)80028-h" @default.
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