FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069118261> ?p ?o ?g. }

• W2069118261 endingPage "14011" @default.
• W2069118261 startingPage "14007" @default.
• W2069118261 abstract "Both synaptic strength and spine size vary from spine to spine, but are strongly correlated. This gradation is regulated by activity and may underlie information storage. Ca 2+ -calmodulin-dependent kinase II (CaMKII) is critically involved in the regulation of synaptic strength and spine size. The high amount of the kinase in the postsynaptic density has suggested that the kinase has a structural role at synapses. We demonstrated previously that the bound amount of CaMKIIα in spines persistently increases after induction of long-term potentiation, prompting the hypothesis that this amount may correlate with synaptic strength. To test this hypothesis we combined two recently developed methods, two-photon uncaging of glutamate for determining the EPSC of individual spines (uEPSC) and quantitative microscopy for measuring bound CaMKIIα in the same spines. We found that under basal conditions the relative bound amount of CaMKIIα varied over a 10-fold range and positively correlated with the uEPSC. Both the bound amount of CaMKIIα in spines and uEPSC also positively correlated with spine size. Interestingly, the bound CaMKIIα fraction (bound/total CaMKIIα in spines) remained remarkably constant across all spines. The results are consistent with the hypothesis that bound CaMKII serves as a structural organizer of postsynaptic molecules and thereby may be involved in maintaining spine size and synaptic strength." @default.
• W2069118261 created "2016-06-24" @default.
• W2069118261 creator A5008834025 @default.
• W2069118261 creator A5019642857 @default.
• W2069118261 creator A5071574342 @default.
• W2069118261 date "2007-12-19" @default.
• W2069118261 modified "2023-10-01" @default.
• W2069118261 title "Synaptic Strength of Individual Spines Correlates with Bound Ca²⁺–Calmodulin-Dependent Kinase II" @default.
• W2069118261 cites W1571673602 @default.
• W2069118261 cites W1659153222 @default.
• W2069118261 cites W1781445228 @default.
• W2069118261 cites W1798313689 @default.
• W2069118261 cites W1975786395 @default.
• W2069118261 cites W1983553517 @default.
• W2069118261 cites W1986605182 @default.
• W2069118261 cites W2002380354 @default.
• W2069118261 cites W2013314618 @default.
• W2069118261 cites W2014163893 @default.
• W2069118261 cites W2014549178 @default.
• W2069118261 cites W2021235911 @default.
• W2069118261 cites W2021307710 @default.
• W2069118261 cites W2051764423 @default.
• W2069118261 cites W2059890547 @default.
• W2069118261 cites W2071910925 @default.
• W2069118261 cites W2076936216 @default.
• W2069118261 cites W2087706333 @default.
• W2069118261 cites W2093807579 @default.
• W2069118261 cites W2105661186 @default.
• W2069118261 cites W2117664079 @default.
• W2069118261 cites W2126761857 @default.
• W2069118261 cites W2133000126 @default.
• W2069118261 cites W2133046879 @default.
• W2069118261 cites W2135004571 @default.
• W2069118261 cites W2143418370 @default.
• W2069118261 cites W2144874949 @default.
• W2069118261 cites W2145255740 @default.
• W2069118261 cites W2146521940 @default.
• W2069118261 cites W2146831587 @default.
• W2069118261 cites W2148256023 @default.
• W2069118261 cites W2152994191 @default.
• W2069118261 doi "https://doi.org/10.1523/jneurosci.3587-07.2007" @default.
• W2069118261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673528" @default.
• W2069118261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18094239" @default.
• W2069118261 hasPublicationYear "2007" @default.
• W2069118261 type Work @default.
• W2069118261 sameAs 2069118261 @default.
• W2069118261 citedByCount "83" @default.
• W2069118261 countsByYear W20691182612012 @default.
• W2069118261 countsByYear W20691182612013 @default.
• W2069118261 countsByYear W20691182612014 @default.
• W2069118261 countsByYear W20691182612015 @default.
• W2069118261 countsByYear W20691182612016 @default.
• W2069118261 countsByYear W20691182612017 @default.
• W2069118261 countsByYear W20691182612018 @default.
• W2069118261 countsByYear W20691182612019 @default.
• W2069118261 countsByYear W20691182612020 @default.
• W2069118261 countsByYear W20691182612021 @default.
• W2069118261 countsByYear W20691182612022 @default.
• W2069118261 countsByYear W20691182612023 @default.
• W2069118261 crossrefType "journal-article" @default.
• W2069118261 hasAuthorship W2069118261A5008834025 @default.
• W2069118261 hasAuthorship W2069118261A5019642857 @default.
• W2069118261 hasAuthorship W2069118261A5071574342 @default.
• W2069118261 hasBestOaLocation W20691182611 @default.
• W2069118261 hasConcept C12554922 @default.
• W2069118261 hasConcept C148762608 @default.
• W2069118261 hasConcept C169760540 @default.
• W2069118261 hasConcept C170493617 @default.
• W2069118261 hasConcept C174884520 @default.
• W2069118261 hasConcept C185592680 @default.
• W2069118261 hasConcept C187541742 @default.
• W2069118261 hasConcept C197341189 @default.
• W2069118261 hasConcept C205383261 @default.
• W2069118261 hasConcept C25274449 @default.
• W2069118261 hasConcept C55493867 @default.
• W2069118261 hasConcept C86803240 @default.
• W2069118261 hasConcept C95444343 @default.
• W2069118261 hasConcept C98229152 @default.
• W2069118261 hasConceptScore W2069118261C12554922 @default.
• W2069118261 hasConceptScore W2069118261C148762608 @default.
• W2069118261 hasConceptScore W2069118261C169760540 @default.
• W2069118261 hasConceptScore W2069118261C170493617 @default.
• W2069118261 hasConceptScore W2069118261C174884520 @default.
• W2069118261 hasConceptScore W2069118261C185592680 @default.
• W2069118261 hasConceptScore W2069118261C187541742 @default.
• W2069118261 hasConceptScore W2069118261C197341189 @default.
• W2069118261 hasConceptScore W2069118261C205383261 @default.
• W2069118261 hasConceptScore W2069118261C25274449 @default.
• W2069118261 hasConceptScore W2069118261C55493867 @default.
• W2069118261 hasConceptScore W2069118261C86803240 @default.
• W2069118261 hasConceptScore W2069118261C95444343 @default.
• W2069118261 hasConceptScore W2069118261C98229152 @default.
• W2069118261 hasIssue "51" @default.
• W2069118261 hasLocation W20691182611 @default.
• W2069118261 hasLocation W20691182612 @default.
• W2069118261 hasLocation W20691182613 @default.
• W2069118261 hasLocation W20691182614 @default.
• W2069118261 hasOpenAccess W2069118261 @default.

• next