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- W2069121275 endingPage "558" @default.
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- W2069121275 abstract "Structural clues to protein function Translocator protein (TSPO) is a mitochondrial membrane protein thought to transport cholesterol and porphyrins. Its detailed function remains unclear, but interest in it is high because TSPO is involved in a variety of human diseases. Two papers now present crystal structures of bacterial TSPOs. Li et al. show that a mutant that mimics a human single polymorphism associated with psychiatric disorders has structural changes in a region implicated in cholesterol binding. Guo et al. suggest that TSPO may be more than a transporter. They show how it catalyzes the degradation of porphyrins, a function that could be important in protection against oxidative stress. Science , this issue p. 555 , p. 551" @default.
- W2069121275 created "2016-06-24" @default.
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- W2069121275 date "2015-01-30" @default.
- W2069121275 modified "2023-10-18" @default.
- W2069121275 title "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism" @default.
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- W2069121275 doi "https://doi.org/10.1126/science.1260590" @default.
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