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• W2069133721 abstract "We have tested the ability of protein I/II, an adhesin from oral streptococci, to stimulate the production of pro-inflammatory cytokines by synovial cells isolated from both rheumatoid arthritis and control patients. Protein I/II triggers synovial fluid cells to produce interleukin (IL)-6 and IL-8 while secretion of tumor necrosis factor-α (TNF-α) was less enhanced. Using fibroblast-like synoviocytes, we found that protein I/II also exerts an immunomodulatory effect (IL-6 and IL-8 release) on these cells. These findings indicate that, if it gains access to the joint cavity, protein I/II could participate in the initiation and/or perpetuation of rheumatic diseases, by stimulating pro-inflammatory cytokine release from various synovial cells." @default.
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• W2069133721 date "2001-02-01" @default.
• W2069133721 modified "2023-10-10" @default.
• W2069133721 title "Pro-inflammatory cytokine production by synoviocytes following exposure to protein I/II, a modulin from oral streptococci" @default.
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• W2069133721 doi "https://doi.org/10.1111/j.1574-695x.2001.tb01544.x" @default.
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