Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069149229> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2069149229 endingPage "214" @default.
- W2069149229 startingPage "189" @default.
- W2069149229 abstract "The cholinergic hypothesis of Alzheimers Disease (AD) has led to a number of animal models to study in vivo the pathogeny of cortical cholinergic involution. The lesion of the cholinergic neurons of the basal forebrain, especially of the nucleus basalis magnocellularis (nbm) of rodents, has been the most utilized method for obtaining these models. Toxic substances such as quinolic, kainic, NMDA, ibotenic and quisqualic acids, the specific cholinergic toxin AF64, amyloid, and antibodies to neurotrophic factors; etc, have been used to produce such lesions. These investigations have helped our understanding of the role of cerebral cholinergic innervation in cognitive disorders and their treatments. However, this research has provided conflicting results, and much controversy has developed surrounding the role of the cholinergic systems and the suitability of these models. It is very important to take into account the exact type of nbm / cortical lesion produced, and its evolution, if meaningful results are to be obtained. This review covers the theoretical and practical use of nbm lesion models, and examines the main positive and negative results obtained by different authors in the light of our own observations on the long-term (3 years) morphological and biochemical changes that occur in several kinds of nbmlesion model rats. The changes seen were very different, but many of them were increased up to the end of life with no clear relationship with the development of the original lesion. Keywords: alzheimer disease (ad), ad animal models, nucleus basalis, basal forebrain, cortical cholinergic innervation, excitotoxins, ad treatments" @default.
- W2069149229 created "2016-06-24" @default.
- W2069149229 creator A5034190081 @default.
- W2069149229 creator A5061547368 @default.
- W2069149229 date "2004-08-01" @default.
- W2069149229 modified "2023-09-25" @default.
- W2069149229 title "Lesions and Dysfunctions of the Nucleus Basalis as Alzheimers Disease Models: General and Critical Overview and Analysis of the Long-Term Changes in Several Excitotoxic Models" @default.
- W2069149229 doi "https://doi.org/10.2174/1567205043332117" @default.
- W2069149229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15975067" @default.
- W2069149229 hasPublicationYear "2004" @default.
- W2069149229 type Work @default.
- W2069149229 sameAs 2069149229 @default.
- W2069149229 citedByCount "35" @default.
- W2069149229 countsByYear W20691492292012 @default.
- W2069149229 countsByYear W20691492292013 @default.
- W2069149229 countsByYear W20691492292014 @default.
- W2069149229 countsByYear W20691492292015 @default.
- W2069149229 countsByYear W20691492292016 @default.
- W2069149229 countsByYear W20691492292019 @default.
- W2069149229 countsByYear W20691492292020 @default.
- W2069149229 countsByYear W20691492292021 @default.
- W2069149229 countsByYear W20691492292023 @default.
- W2069149229 crossrefType "journal-article" @default.
- W2069149229 hasAuthorship W2069149229A5034190081 @default.
- W2069149229 hasAuthorship W2069149229A5061547368 @default.
- W2069149229 hasConcept C104966671 @default.
- W2069149229 hasConcept C142724271 @default.
- W2069149229 hasConcept C15744967 @default.
- W2069149229 hasConcept C169760540 @default.
- W2069149229 hasConcept C170493617 @default.
- W2069149229 hasConcept C22885893 @default.
- W2069149229 hasConcept C2776108384 @default.
- W2069149229 hasConcept C2776287375 @default.
- W2069149229 hasConcept C2777681179 @default.
- W2069149229 hasConcept C2778205193 @default.
- W2069149229 hasConcept C2779134260 @default.
- W2069149229 hasConcept C2781156865 @default.
- W2069149229 hasConcept C502032728 @default.
- W2069149229 hasConcept C529278444 @default.
- W2069149229 hasConcept C55493867 @default.
- W2069149229 hasConcept C61174792 @default.
- W2069149229 hasConcept C71924100 @default.
- W2069149229 hasConcept C86803240 @default.
- W2069149229 hasConceptScore W2069149229C104966671 @default.
- W2069149229 hasConceptScore W2069149229C142724271 @default.
- W2069149229 hasConceptScore W2069149229C15744967 @default.
- W2069149229 hasConceptScore W2069149229C169760540 @default.
- W2069149229 hasConceptScore W2069149229C170493617 @default.
- W2069149229 hasConceptScore W2069149229C22885893 @default.
- W2069149229 hasConceptScore W2069149229C2776108384 @default.
- W2069149229 hasConceptScore W2069149229C2776287375 @default.
- W2069149229 hasConceptScore W2069149229C2777681179 @default.
- W2069149229 hasConceptScore W2069149229C2778205193 @default.
- W2069149229 hasConceptScore W2069149229C2779134260 @default.
- W2069149229 hasConceptScore W2069149229C2781156865 @default.
- W2069149229 hasConceptScore W2069149229C502032728 @default.
- W2069149229 hasConceptScore W2069149229C529278444 @default.
- W2069149229 hasConceptScore W2069149229C55493867 @default.
- W2069149229 hasConceptScore W2069149229C61174792 @default.
- W2069149229 hasConceptScore W2069149229C71924100 @default.
- W2069149229 hasConceptScore W2069149229C86803240 @default.
- W2069149229 hasIssue "3" @default.
- W2069149229 hasLocation W20691492291 @default.
- W2069149229 hasLocation W20691492292 @default.
- W2069149229 hasOpenAccess W2069149229 @default.
- W2069149229 hasPrimaryLocation W20691492291 @default.
- W2069149229 hasRelatedWork W1964640629 @default.
- W2069149229 hasRelatedWork W1990922657 @default.
- W2069149229 hasRelatedWork W2020153518 @default.
- W2069149229 hasRelatedWork W2027009747 @default.
- W2069149229 hasRelatedWork W2052625961 @default.
- W2069149229 hasRelatedWork W2069149229 @default.
- W2069149229 hasRelatedWork W2080113867 @default.
- W2069149229 hasRelatedWork W2085887884 @default.
- W2069149229 hasRelatedWork W2487514720 @default.
- W2069149229 hasRelatedWork W52193932 @default.
- W2069149229 hasVolume "1" @default.
- W2069149229 isParatext "false" @default.
- W2069149229 isRetracted "false" @default.
- W2069149229 magId "2069149229" @default.
- W2069149229 workType "article" @default.