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- W2069153289 abstract "When isolated intestinal cells from 3-wk-old chickens are treated with exogenous ATP they undergo a dramatic increase in permeability towards Na+. The increase occurs instantaneously and maximum cell loading with Na+ occurs within 2 min. The response is dose dependent (0.1–1.0 mm-ATP) and results in as much as a 10-fold increase in unidirectional influx of 22Na+ into the cells. The resting cellular Na+ gradient and membrane potential are partially dissipated and consequently Na+-dependent transport of sugars and amino acids is inhibited. Sodium saccharin (20 mm), added at the same time as ATP, completely blocks the effect of ATP on Na+ permeability and preserves the functional capacity of the cells for Na+-dependent sugar or amino acid transport. Partial protection is afforded by 10 mm-saccharin. Saccharin added 2 min after ATP will reverse the enhanced Na+ permeability that has already been induced. In cells that have not been treated with ATP, saccharin induces enhanced sugar and amino acid gradients (P < 0.05 in paired comparisons from the same cell preparation), indicating that it may also inhibit Na+ permeability of the unperturbed membrane and allow cells to establish higher Na+ gradients and/or membrane potentials. The effects of saccharin in blocking ATP-induced Na+ permeability occurs within 10 sec and at a much lower dose than that required for blockade of facilitated diffusional sugar transfer in these cells." @default.
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- W2069153289 title "Effect of saccharin on the ATP-induced increase in Na+ permeability in isolated chicken intestinal epithelial cells" @default.
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- W2069153289 doi "https://doi.org/10.1016/0278-6915(89)90062-8" @default.
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