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- W2069164964 abstract "G A A b st ra ct s study was to determine if EWBP in patients with nutcracker esophagus was different when compared to normal subjects. Furthermore, we examined esophageal mucosa biopsy specimens for evidence of HIF 1a, a marker of hypoxia in normal subject and patients. Methods: studies were performed in 12 normal healthy subjects (mean age = 51, 11 males) and 12 patients (mean age = 52, 9 males) with angina-like with a negative cardiac work up and manometric diagnosis of nutcracker esophagus. A laser Doppler probe was anchored to the esophageal wall, 5cm above the LES, as described previously. A HRM catheter was placed via the nose into the esophagus. Recordings were performed for one hour in the fasting and 2 hours following a meal. Esophageal mucosa biopsy, (5cm above LES) was obtained on a separate day during sedated endoscopy. Biopsy specimens were immunostained for marker of tissue hypoxia (immunostaining for hypoxia -inducible factor HIF 1a) by fluorescent labeling and imaged by confocal microscopy. Results: Mean esophageal wall perfusion (EWP) was lower in patients compared to normal subjects, in both fasting and post-prandial state. Frequency distribution of the esophageal wall perfusion values revealed a curve shifted to the left as compared to normal subjects (figure 1). Mucosa biopsy specimens revealed dramatically increased immuno-staining for hypoxia-inducible factor (HIF 1a) (Figure 2) and other markers of hypoxia related injury in patients as compared to normal subjects. Conclusions: we propose that low EWBP; or ischemia of the esophageal wall is a possible cause of esophageal pain and hypoxia related injury to the esophageal mucosa." @default.
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- W2069164964 date "2015-04-01" @default.
- W2069164964 modified "2023-10-16" @default.
- W2069164964 title "372 High Resolution Esophageal Manometry With a Standardized Test Meal Increases Diagnostic Sensitivity for Clinical Relevant Esophageal Motility Disorders" @default.
- W2069164964 doi "https://doi.org/10.1016/s0016-5085(15)30266-3" @default.
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