Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069174518> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2069174518 endingPage "792" @default.
- W2069174518 startingPage "787" @default.
- W2069174518 abstract "Aberrantly folded proteins in the endoplasmic reticulum (ER) are rapidly removed into the cytosol for degradation by the proteasome via an evolutionarily conserved process termed ER-associated protein degradation (ERAD). ERAD of a subset of proteins requires Derlin-1 for dislocation into the cytosol; however, the molecular function of Derlin-1 remains unclear. Human cytomegalovirus US11 exploits Derlin-1-dependent ERAD to degrade major histocompatibility complex class I (MHC-I) molecules for immune evasion. Because US11 binds to both MHC-I molecules and Derlin-1 via its luminal and transmembrane domains (TMDs), respectively, the major role of US11 has been proposed to simply be delivery of MHC-I molecules to Derlin-1. Here, we directly tested this proposal by generating a hybrid MHC-I molecule, which contains the US11 TMD, and thus can associate with Derlin-1 in the absence of US11. Intriguingly, this MHC-I hybrid was rapidly degraded in a Derlin-1- and proteasome-dependent manner. Similarly, the vesicular stomatitis virus G protein, otherwise expressed at the cell surface, was degraded via Derlin-1-dependent ERAD when its TMD was replaced with that of US11. Thus, forced interaction of cell surface proteins with Derlin-1 is sufficient to induce their degradation via ERAD. Taken together, these results suggest that the main role of US11 is to recruit MHC-I molecules to Derlin-1, which then mediates the dislocation of MHC-I molecules into the cytosol for degradation." @default.
- W2069174518 created "2016-06-24" @default.
- W2069174518 creator A5010846406 @default.
- W2069174518 creator A5012981059 @default.
- W2069174518 creator A5061469739 @default.
- W2069174518 date "2013-01-01" @default.
- W2069174518 modified "2023-10-03" @default.
- W2069174518 title "Forced interaction of cell surface proteins with Derlin-1 in the endoplasmic reticulum is sufficient to induce their dislocation into the cytosol for degradation" @default.
- W2069174518 cites W1668688100 @default.
- W2069174518 cites W1980337003 @default.
- W2069174518 cites W1981625315 @default.
- W2069174518 cites W1995852844 @default.
- W2069174518 cites W2008774884 @default.
- W2069174518 cites W2009794312 @default.
- W2069174518 cites W2015086970 @default.
- W2069174518 cites W2022345195 @default.
- W2069174518 cites W2022931463 @default.
- W2069174518 cites W2023397454 @default.
- W2069174518 cites W2026357888 @default.
- W2069174518 cites W2033088972 @default.
- W2069174518 cites W2036723816 @default.
- W2069174518 cites W2042514375 @default.
- W2069174518 cites W2045151558 @default.
- W2069174518 cites W2051881845 @default.
- W2069174518 cites W2058856541 @default.
- W2069174518 cites W2059699662 @default.
- W2069174518 cites W2064609154 @default.
- W2069174518 cites W2078039611 @default.
- W2069174518 cites W2081104776 @default.
- W2069174518 cites W2082001606 @default.
- W2069174518 cites W2117313136 @default.
- W2069174518 cites W2156770495 @default.
- W2069174518 cites W2167754556 @default.
- W2069174518 cites W2170432403 @default.
- W2069174518 doi "https://doi.org/10.1016/j.bbrc.2012.11.068" @default.
- W2069174518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23206703" @default.
- W2069174518 hasPublicationYear "2013" @default.
- W2069174518 type Work @default.
- W2069174518 sameAs 2069174518 @default.
- W2069174518 citedByCount "12" @default.
- W2069174518 countsByYear W20691745182013 @default.
- W2069174518 countsByYear W20691745182014 @default.
- W2069174518 countsByYear W20691745182015 @default.
- W2069174518 countsByYear W20691745182016 @default.
- W2069174518 countsByYear W20691745182020 @default.
- W2069174518 countsByYear W20691745182022 @default.
- W2069174518 crossrefType "journal-article" @default.
- W2069174518 hasAuthorship W2069174518A5010846406 @default.
- W2069174518 hasAuthorship W2069174518A5012981059 @default.
- W2069174518 hasAuthorship W2069174518A5061469739 @default.
- W2069174518 hasConcept C104317684 @default.
- W2069174518 hasConcept C139447449 @default.
- W2069174518 hasConcept C158617107 @default.
- W2069174518 hasConcept C158619295 @default.
- W2069174518 hasConcept C170627219 @default.
- W2069174518 hasConcept C181199279 @default.
- W2069174518 hasConcept C207936829 @default.
- W2069174518 hasConcept C27740335 @default.
- W2069174518 hasConcept C2992195973 @default.
- W2069174518 hasConcept C55493867 @default.
- W2069174518 hasConcept C86803240 @default.
- W2069174518 hasConcept C95444343 @default.
- W2069174518 hasConcept C98539663 @default.
- W2069174518 hasConceptScore W2069174518C104317684 @default.
- W2069174518 hasConceptScore W2069174518C139447449 @default.
- W2069174518 hasConceptScore W2069174518C158617107 @default.
- W2069174518 hasConceptScore W2069174518C158619295 @default.
- W2069174518 hasConceptScore W2069174518C170627219 @default.
- W2069174518 hasConceptScore W2069174518C181199279 @default.
- W2069174518 hasConceptScore W2069174518C207936829 @default.
- W2069174518 hasConceptScore W2069174518C27740335 @default.
- W2069174518 hasConceptScore W2069174518C2992195973 @default.
- W2069174518 hasConceptScore W2069174518C55493867 @default.
- W2069174518 hasConceptScore W2069174518C86803240 @default.
- W2069174518 hasConceptScore W2069174518C95444343 @default.
- W2069174518 hasConceptScore W2069174518C98539663 @default.
- W2069174518 hasIssue "2" @default.
- W2069174518 hasLocation W20691745181 @default.
- W2069174518 hasLocation W20691745182 @default.
- W2069174518 hasOpenAccess W2069174518 @default.
- W2069174518 hasPrimaryLocation W20691745181 @default.
- W2069174518 hasRelatedWork W1495830724 @default.
- W2069174518 hasRelatedWork W1558470115 @default.
- W2069174518 hasRelatedWork W1977498240 @default.
- W2069174518 hasRelatedWork W2016735583 @default.
- W2069174518 hasRelatedWork W2110310839 @default.
- W2069174518 hasRelatedWork W2139653729 @default.
- W2069174518 hasRelatedWork W2391179902 @default.
- W2069174518 hasRelatedWork W254315063 @default.
- W2069174518 hasRelatedWork W2897243648 @default.
- W2069174518 hasRelatedWork W4236329731 @default.
- W2069174518 hasVolume "430" @default.
- W2069174518 isParatext "false" @default.
- W2069174518 isRetracted "false" @default.
- W2069174518 magId "2069174518" @default.
- W2069174518 workType "article" @default.