FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069174611> ?p ?o ?g. }

• W2069174611 endingPage "295" @default.
• W2069174611 startingPage "281" @default.
• W2069174611 abstract "Oxidative stress and subsequent energy crisis have been proposed as the cause of nigral neuronal cell death in Parkinson's disease. We have reported defects in the mitochondrial respiratory chain and increased amount of deleted mitochondrial genome in the nigrostriatal system of patients with Parkinson's disease. Deletion in mitochondrial DNA could be ascribed to somatically acquired premature aging leading to cell death. To elucidate the contribution of maternally transmitted point mutations in mitochondrial DNA to the premature DNA damages, we employed a direct sequencing system and analyzed the total nucleotide sequences of mitochondrial DNA in the brains of five patients with idiopathic Parkinson's disease. There were no predominant point mutations among the patients in contrast to some neuromuscular diseases. However, each patient had several point mutations that would result in a significant change in the gene products. Some of these mutations may be involved either in the increased production of oxygen radicals from the mitochondrial respiratory chain or in the increased susceptibility of the respiratory chain components to oxidative damage. We propose that some of these mutations can be regarded as one of the risk factors accelerating degeneration of nigrostriatal pathway in Parkinson's disease." @default.
• W2069174611 created "2016-06-24" @default.
• W2069174611 creator A5035613772 @default.
• W2069174611 creator A5037702505 @default.
• W2069174611 creator A5057218151 @default.
• W2069174611 date "1995-02-01" @default.
• W2069174611 modified "2023-09-26" @default.
• W2069174611 title "Point mutations of mitochondrial genome in Parkinson's disease" @default.
• W2069174611 cites W1497179990 @default.
• W2069174611 cites W1541027473 @default.
• W2069174611 cites W1597843181 @default.
• W2069174611 cites W1965663262 @default.
• W2069174611 cites W1972900422 @default.
• W2069174611 cites W1974396693 @default.
• W2069174611 cites W1975304761 @default.
• W2069174611 cites W1976926871 @default.
• W2069174611 cites W1978336924 @default.
• W2069174611 cites W1978675778 @default.
• W2069174611 cites W1985613988 @default.
• W2069174611 cites W1987462737 @default.
• W2069174611 cites W1989841259 @default.
• W2069174611 cites W1995801413 @default.
• W2069174611 cites W1996052541 @default.
• W2069174611 cites W2002669050 @default.
• W2069174611 cites W2007510125 @default.
• W2069174611 cites W2011906490 @default.
• W2069174611 cites W2016905315 @default.
• W2069174611 cites W2017347785 @default.
• W2069174611 cites W2020208382 @default.
• W2069174611 cites W2025130486 @default.
• W2069174611 cites W2025907197 @default.
• W2069174611 cites W2026674234 @default.
• W2069174611 cites W2031229678 @default.
• W2069174611 cites W2033272613 @default.
• W2069174611 cites W2033317847 @default.
• W2069174611 cites W2033762342 @default.
• W2069174611 cites W2044573154 @default.
• W2069174611 cites W2056917554 @default.
• W2069174611 cites W2057162464 @default.
• W2069174611 cites W2064655402 @default.
• W2069174611 cites W2068286361 @default.
• W2069174611 cites W2071953515 @default.
• W2069174611 cites W2074833985 @default.
• W2069174611 cites W2080904974 @default.
• W2069174611 cites W2081249304 @default.
• W2069174611 cites W2082887891 @default.
• W2069174611 cites W2086178730 @default.
• W2069174611 cites W2094232655 @default.
• W2069174611 cites W2095130584 @default.
• W2069174611 cites W2104018711 @default.
• W2069174611 cites W2109291482 @default.
• W2069174611 cites W2136372119 @default.
• W2069174611 cites W2162973898 @default.
• W2069174611 cites W2167974473 @default.
• W2069174611 cites W2168195159 @default.
• W2069174611 cites W2171790255 @default.
• W2069174611 doi "https://doi.org/10.1016/0169-328x(94)00209-w" @default.
• W2069174611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7723627" @default.
• W2069174611 hasPublicationYear "1995" @default.
• W2069174611 type Work @default.
• W2069174611 sameAs 2069174611 @default.
• W2069174611 citedByCount "141" @default.
• W2069174611 countsByYear W20691746112012 @default.
• W2069174611 countsByYear W20691746112013 @default.
• W2069174611 countsByYear W20691746112014 @default.
• W2069174611 countsByYear W20691746112015 @default.
• W2069174611 countsByYear W20691746112016 @default.
• W2069174611 countsByYear W20691746112017 @default.
• W2069174611 countsByYear W20691746112018 @default.
• W2069174611 countsByYear W20691746112019 @default.
• W2069174611 countsByYear W20691746112020 @default.
• W2069174611 countsByYear W20691746112021 @default.
• W2069174611 countsByYear W20691746112022 @default.
• W2069174611 countsByYear W20691746112023 @default.
• W2069174611 crossrefType "journal-article" @default.
• W2069174611 hasAuthorship W2069174611A5035613772 @default.
• W2069174611 hasAuthorship W2069174611A5037702505 @default.
• W2069174611 hasAuthorship W2069174611A5057218151 @default.
• W2069174611 hasConcept C104317684 @default.
• W2069174611 hasConcept C134018914 @default.
• W2069174611 hasConcept C142724271 @default.
• W2069174611 hasConcept C151994961 @default.
• W2069174611 hasConcept C176944494 @default.
• W2069174611 hasConcept C181561989 @default.
• W2069174611 hasConcept C24586158 @default.
• W2069174611 hasConcept C2776151105 @default.
• W2069174611 hasConcept C2779134260 @default.
• W2069174611 hasConcept C2779734285 @default.
• W2069174611 hasConcept C28859421 @default.
• W2069174611 hasConcept C3020377403 @default.
• W2069174611 hasConcept C3020761558 @default.
• W2069174611 hasConcept C501734568 @default.
• W2069174611 hasConcept C54355233 @default.
• W2069174611 hasConcept C71924100 @default.
• W2069174611 hasConcept C86803240 @default.
• W2069174611 hasConceptScore W2069174611C104317684 @default.
• W2069174611 hasConceptScore W2069174611C134018914 @default.
• W2069174611 hasConceptScore W2069174611C142724271 @default.

• next