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- W2069183779 abstract "Among the functions of intracellular proteolysis are the elimination of misfolded or otherwise abnormal proteins; the maintenance of amino acid pools in cells affected by stresses, such as starvation; and the generation of protein fragments that act as hormones, antigens, or other effectors. Many intracellular proteins are either conditionally or constitutively short-lived, with in vivo half-lives that can be as brief as a few minutes. In some cases, a proteolytic pathway targets and destroys a protein cotranslationally, i.e., an emerging polypeptide chain can be degraded while it is still a ribosome-associatedpeptidyl-tRNA (1, 2). The regulated and processive degradation of intracellular proteins is carried out largely by the ubiquitin (Ub)- proteasome system (Ub system), in conjunction with molecular chaperones, autophagy, and lysosomal proteolysis. Other mediators ofintracellular protein degradation include proteases such as caspases, calpains, and separases. These and other nonprocessive proteases can function as “upstream” components of the Ub system, generating protein fragments that are targeted and degraded to short peptides by Ub-mediated pathways. Proteins that are damaged, misfolded, or otherwise abnormal are often recognized as such and selectively destroyed by the Ub system. Physiologicallyimportant exceptions include conformationally perturbed proteins and/or their aggregates that are harmful but cannot be efficaciously repaired or removed. The resulting proteotoxicity underlies both aging and specific diseases,including neurodegeneration." @default.
- W2069183779 created "2016-06-24" @default.
- W2069183779 creator A5039562263 @default.
- W2069183779 date "2012-07-07" @default.
- W2069183779 modified "2023-10-03" @default.
- W2069183779 title "The Ubiquitin System, an Immense Realm" @default.
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- W2069183779 doi "https://doi.org/10.1146/annurev-biochem-051910-094049" @default.
- W2069183779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22663079" @default.
- W2069183779 hasPublicationYear "2012" @default.
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