FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069187872> ?p ?o ?g. }

• W2069187872 endingPage "526" @default.
• W2069187872 startingPage "519" @default.
• W2069187872 abstract "Eukaryotic initiation factor (eIF) 4E binds to the 5'-cap structure of eukaryotic mRNA and has a central role in the control of cell proliferation. We have shown previously that the stimulation of cultured Xenopus kidney cells with serum resulted in the activation of protein synthesis, enhanced phosphorylation of eIF4E and increased binding of the adapter protein, eIF4G, and poly(A)-binding protein (PABP) to eIF4E to form the functional initiation factor complex, eIF4F/PABP. We now show that cellular stresses such as arsenite, anisomycin and heat shock also result in increased phosphorylation of eIF4E, eIF4F complex formation and the association of PABP with eIF4G, in conditions under which the rate of protein synthesis is severely inhibited. In contrast with reported effects on mammalian cells, the stress-induced increase in eIF4F complex formation occurs in the absence of changes in the association of eIF4E with its binding proteins 4E-BP1 or 4E-BP2. The stress-induced changes in eIF4E phosphorylation were totally abrogated by the p38 mitogen-activated protein (MAP) kinase inhibitor SB203580, and were partly inhibited by the phosphoinositide 3-kinase inhibitor LY294002 and the mammalian target of rapamycin (mTOR) inhibitor rapamycin. However, eIF4E phosphorylation was unaffected by extracellular signal-regulated protein kinase (MAP kinase) inhibitor PD98059. These results indicate that cellular stresses activate multiple signalling pathways that converge at the level of eIF4F complex formation to influence the interactions between eIF4E, eIF4G and PABP." @default.
• W2069187872 created "2016-06-24" @default.
• W2069187872 creator A5022049964 @default.
• W2069187872 creator A5030829931 @default.
• W2069187872 creator A5088437991 @default.
• W2069187872 date "1999-09-05" @default.
• W2069187872 modified "2023-09-25" @default.
• W2069187872 title "Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein" @default.
• W2069187872 cites W146972387 @default.
• W2069187872 cites W1500261766 @default.
• W2069187872 cites W1510533371 @default.
• W2069187872 cites W1566502635 @default.
• W2069187872 cites W1583592656 @default.
• W2069187872 cites W1607579928 @default.
• W2069187872 cites W1912098244 @default.
• W2069187872 cites W1923586165 @default.
• W2069187872 cites W1964146094 @default.
• W2069187872 cites W1965177762 @default.
• W2069187872 cites W1965894414 @default.
• W2069187872 cites W1966059275 @default.
• W2069187872 cites W1970027651 @default.
• W2069187872 cites W1970548320 @default.
• W2069187872 cites W1981001162 @default.
• W2069187872 cites W1981667551 @default.
• W2069187872 cites W1989186349 @default.
• W2069187872 cites W1989523668 @default.
• W2069187872 cites W1990239053 @default.
• W2069187872 cites W1990766122 @default.
• W2069187872 cites W1993836723 @default.
• W2069187872 cites W1995296724 @default.
• W2069187872 cites W1998293722 @default.
• W2069187872 cites W2010217335 @default.
• W2069187872 cites W2014007212 @default.
• W2069187872 cites W2021669986 @default.
• W2069187872 cites W2022914311 @default.
• W2069187872 cites W2032666422 @default.
• W2069187872 cites W2040579733 @default.
• W2069187872 cites W2049747157 @default.
• W2069187872 cites W2050342865 @default.
• W2069187872 cites W2053304186 @default.
• W2069187872 cites W2057080108 @default.
• W2069187872 cites W2066018734 @default.
• W2069187872 cites W2069652470 @default.
• W2069187872 cites W2086707089 @default.
• W2069187872 cites W2091805564 @default.
• W2069187872 cites W2099136664 @default.
• W2069187872 cites W2102280349 @default.
• W2069187872 cites W2112013596 @default.
• W2069187872 cites W2114492564 @default.
• W2069187872 cites W2119006335 @default.
• W2069187872 cites W2123742352 @default.
• W2069187872 cites W2133181350 @default.
• W2069187872 cites W2154385447 @default.
• W2069187872 cites W2157311365 @default.
• W2069187872 cites W2160270312 @default.
• W2069187872 cites W2161445615 @default.
• W2069187872 cites W2337853871 @default.
• W2069187872 cites W2356502417 @default.
• W2069187872 cites W2400574198 @default.
• W2069187872 cites W2411637333 @default.
• W2069187872 doi "https://doi.org/10.1042/bj3420519" @default.
• W2069187872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220492" @default.
• W2069187872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477262" @default.
• W2069187872 hasPublicationYear "1999" @default.
• W2069187872 type Work @default.
• W2069187872 sameAs 2069187872 @default.
• W2069187872 citedByCount "27" @default.
• W2069187872 countsByYear W20691878722015 @default.
• W2069187872 countsByYear W20691878722017 @default.
• W2069187872 crossrefType "journal-article" @default.
• W2069187872 hasAuthorship W2069187872A5022049964 @default.
• W2069187872 hasAuthorship W2069187872A5030829931 @default.
• W2069187872 hasAuthorship W2069187872A5088437991 @default.
• W2069187872 hasBestOaLocation W20691878722 @default.
• W2069187872 hasConcept C104317684 @default.
• W2069187872 hasConcept C105580179 @default.
• W2069187872 hasConcept C11960822 @default.
• W2069187872 hasConcept C149364088 @default.
• W2069187872 hasConcept C161295673 @default.
• W2069187872 hasConcept C184235292 @default.
• W2069187872 hasConcept C2776054693 @default.
• W2069187872 hasConcept C2778073123 @default.
• W2069187872 hasConcept C55493867 @default.
• W2069187872 hasConcept C86803240 @default.
• W2069187872 hasConcept C95444343 @default.
• W2069187872 hasConcept C97029542 @default.
• W2069187872 hasConcept C97154109 @default.
• W2069187872 hasConceptScore W2069187872C104317684 @default.
• W2069187872 hasConceptScore W2069187872C105580179 @default.
• W2069187872 hasConceptScore W2069187872C11960822 @default.
• W2069187872 hasConceptScore W2069187872C149364088 @default.
• W2069187872 hasConceptScore W2069187872C161295673 @default.
• W2069187872 hasConceptScore W2069187872C184235292 @default.
• W2069187872 hasConceptScore W2069187872C2776054693 @default.
• W2069187872 hasConceptScore W2069187872C2778073123 @default.
• W2069187872 hasConceptScore W2069187872C55493867 @default.
• W2069187872 hasConceptScore W2069187872C86803240 @default.
• W2069187872 hasConceptScore W2069187872C95444343 @default.

• next