FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069188025> ?p ?o ?g. }

• W2069188025 endingPage "141" @default.
• W2069188025 startingPage "136" @default.
• W2069188025 abstract "Crotonis Fructus is the mature fruit of Croton tiglium L. (Euphorbiaceae), which has been used in traditional Chinese medicine for the treatment of gastrointestinal (GI) diseases, such as constipation, abdominal pain, peptic ulcer, and intestinal inflammation for thousands of years. The aim of this study was to investigate the pharmacological effect of extracts and fractions from Crotonis Fructus on GI tract. The activities of methanol extract and fractions from Crotonis Fructus on the smooth muscle contractions were evaluated using isolated rabbit jejunum model. The results suggest that the n-BuOH and H2O fractions showed spasmolytic activity, while the MeOH extract, PE and EtOAc fractions exerted spasmogenic effect. Moreover, bioassay-guided fractionation verified that the EtOAc fraction was more potent than others, followed by PE fraction and methanol extract. Additionally, atropine (10 μM), 4-DAMP (10 μM) and verapamil (0.1 μM) produced a significant inhibition of contractions caused by EtOAc fraction, while either hexamethonium (10 μM) or methoctramine (10 μM) was inactive. Additionally, a HPLC fingerprint of EtOAc fraction was appraised to ensure its chemical consistency and the main component has been identified as phorbol 12-acetate-13-tiglate. These data indicate that the regulatory effect of EtOAc fraction on GI motility are medicated via the activation of M3 muscarinic receptor and Ca2+ influx through L-type Ca2+ channel. These provide a scientific basis for the traditional use of Crotonis Fructus in GI disorders." @default.
• W2069188025 created "2016-06-24" @default.
• W2069188025 creator A5022151390 @default.
• W2069188025 creator A5051117286 @default.
• W2069188025 creator A5077854313 @default.
• W2069188025 creator A5084868970 @default.
• W2069188025 creator A5090105678 @default.
• W2069188025 creator A5090439825 @default.
• W2069188025 date "2012-01-01" @default.
• W2069188025 modified "2023-09-24" @default.
• W2069188025 title "Activation of M3 muscarinic receptor and Ca2+ influx by crude fraction from Crotonis Fructus in isolated rabbit jejunum" @default.
• W2069188025 cites W1528784917 @default.
• W2069188025 cites W171421953 @default.
• W2069188025 cites W1964127298 @default.
• W2069188025 cites W1968658878 @default.
• W2069188025 cites W1969899832 @default.
• W2069188025 cites W1970757039 @default.
• W2069188025 cites W2003741101 @default.
• W2069188025 cites W2008873185 @default.
• W2069188025 cites W2040356743 @default.
• W2069188025 cites W2047456663 @default.
• W2069188025 cites W2052767977 @default.
• W2069188025 cites W2054225339 @default.
• W2069188025 cites W2054858177 @default.
• W2069188025 cites W2061445816 @default.
• W2069188025 cites W2062622155 @default.
• W2069188025 cites W2063448159 @default.
• W2069188025 cites W2065227344 @default.
• W2069188025 cites W2065640440 @default.
• W2069188025 cites W2075946709 @default.
• W2069188025 cites W2078302791 @default.
• W2069188025 cites W2093884624 @default.
• W2069188025 cites W2106835468 @default.
• W2069188025 cites W2157352021 @default.
• W2069188025 cites W2164937988 @default.
• W2069188025 cites W2169743305 @default.
• W2069188025 doi "https://doi.org/10.1016/j.jep.2011.10.041" @default.
• W2069188025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22107834" @default.
• W2069188025 hasPublicationYear "2012" @default.
• W2069188025 type Work @default.
• W2069188025 sameAs 2069188025 @default.
• W2069188025 citedByCount "14" @default.
• W2069188025 countsByYear W20691880252012 @default.
• W2069188025 countsByYear W20691880252013 @default.
• W2069188025 countsByYear W20691880252014 @default.
• W2069188025 countsByYear W20691880252015 @default.
• W2069188025 countsByYear W20691880252016 @default.
• W2069188025 countsByYear W20691880252018 @default.
• W2069188025 countsByYear W20691880252019 @default.
• W2069188025 countsByYear W20691880252020 @default.
• W2069188025 countsByYear W20691880252022 @default.
• W2069188025 countsByYear W20691880252023 @default.
• W2069188025 crossrefType "journal-article" @default.
• W2069188025 hasAuthorship W2069188025A5022151390 @default.
• W2069188025 hasAuthorship W2069188025A5051117286 @default.
• W2069188025 hasAuthorship W2069188025A5077854313 @default.
• W2069188025 hasAuthorship W2069188025A5084868970 @default.
• W2069188025 hasAuthorship W2069188025A5090105678 @default.
• W2069188025 hasAuthorship W2069188025A5090439825 @default.
• W2069188025 hasConcept C116073593 @default.
• W2069188025 hasConcept C126322002 @default.
• W2069188025 hasConcept C160492267 @default.
• W2069188025 hasConcept C170493617 @default.
• W2069188025 hasConcept C185592680 @default.
• W2069188025 hasConcept C202751555 @default.
• W2069188025 hasConcept C2775859210 @default.
• W2069188025 hasConcept C2775893369 @default.
• W2069188025 hasConcept C2775910092 @default.
• W2069188025 hasConcept C2776366702 @default.
• W2069188025 hasConcept C33789571 @default.
• W2069188025 hasConcept C55493867 @default.
• W2069188025 hasConcept C556039675 @default.
• W2069188025 hasConcept C71924100 @default.
• W2069188025 hasConcept C98274493 @default.
• W2069188025 hasConceptScore W2069188025C116073593 @default.
• W2069188025 hasConceptScore W2069188025C126322002 @default.
• W2069188025 hasConceptScore W2069188025C160492267 @default.
• W2069188025 hasConceptScore W2069188025C170493617 @default.
• W2069188025 hasConceptScore W2069188025C185592680 @default.
• W2069188025 hasConceptScore W2069188025C202751555 @default.
• W2069188025 hasConceptScore W2069188025C2775859210 @default.
• W2069188025 hasConceptScore W2069188025C2775893369 @default.
• W2069188025 hasConceptScore W2069188025C2775910092 @default.
• W2069188025 hasConceptScore W2069188025C2776366702 @default.
• W2069188025 hasConceptScore W2069188025C33789571 @default.
• W2069188025 hasConceptScore W2069188025C55493867 @default.
• W2069188025 hasConceptScore W2069188025C556039675 @default.
• W2069188025 hasConceptScore W2069188025C71924100 @default.
• W2069188025 hasConceptScore W2069188025C98274493 @default.
• W2069188025 hasFunder F4320321001 @default.
• W2069188025 hasIssue "1" @default.
• W2069188025 hasLocation W20691880251 @default.
• W2069188025 hasLocation W20691880252 @default.
• W2069188025 hasOpenAccess W2069188025 @default.
• W2069188025 hasPrimaryLocation W20691880251 @default.
• W2069188025 hasRelatedWork W1565083451 @default.
• W2069188025 hasRelatedWork W1979428036 @default.
• W2069188025 hasRelatedWork W2023033699 @default.

• next