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- W2069202303 abstract "ISEE-0259 Background and Objective: GerES IV was a module of the Health Survey for Children and Adolescents (KiGGS). In GerES exposures to chemical, physical and also biological agents were determined on a representative basis. Sensitisation of children aged 3 to 14 years against specific indoor fungi (Walemia sebi, Eurotium spec., Cladosporium herbarum, Aspergillus versicolor, Aspergillus fumigatus, Penicillium chrysogenum) was measured in 1538 serum samples. Methods: A positive result (IgE ≥ 0,35 IU/ml) for one of the fungi was the criteria to define a case for an embedded case-control study. Controls were matched according to age, gender and region in a proportion of 1:3. Thus the case control study consisted of 66 cases and 198 controls. The homes of these 264 children were visited and indoor air and household dust was analysed for mould spores. Results: 8.3% of the 1538 children were tested positive for a sensitisation against at least one of the fungi. Four of these fungi are not part of commercial test kits. 40% of these children did not show a sensitisation against other allergens that are part of commercial allergen test kits. There was a significant correlation between visible mould in the living/children rooms as well as between a basic reconstruction of the home and sensitisation. Spore counts and extent of visible mould were significantly correlated. Conclusions: The analysis of sensitisation against indoor fungi should be part of commercial allergy tests. The results show that long term exposure against fungi is a risk factor for a sensitisation and that exposure to substances used for reconstruction might promote the development of sensitisations. The financial support of the Federal Ministries for the Environment, Nature Conservation and Nuclear Safety and of Education and Research is gratefully acknowledged. Field work of GerES was carried out by the Robert Koch Institute, Berlin and the case-control-study by Rabe HygieneConsult, Essen." @default.
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- W2069202303 date "2009-11-01" @default.
- W2069202303 modified "2023-09-27" @default.
- W2069202303 title "German Environmental Survey for Children (GerES IV): Fungi in Homes and Sensitisation of Children in Germany" @default.
- W2069202303 doi "https://doi.org/10.1097/01.ede.0000362460.01515.87" @default.
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