Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069202398> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2069202398 endingPage "34" @default.
- W2069202398 startingPage "34" @default.
- W2069202398 abstract "Cells of a small cell lung carcinoma cell line, U-1285, and an undifferentiated large cell lung carcinoma cell line, U-1810, differ in radiosensitivity in parallel to the clinical radiosensitivity of the kind of tumors from which they are derived. The surviving fraction at 2 Gy (SF2) was 0.25 that of U-1285 cells and 0.88 that of U-1810 cells. We investigated the induction of DNA double-strand breaks (DSBs) by X rays and DSB rejoining in these cell lines. To estimate the number of DSBs we used a model adapted for pulsed-field gel electrophoresis (PFGE). The induction levels were of the same magnitude (0.46 and 0.51 DSB/100 Mbp/Gy for U-1810 and U-1285 cells, respectively). These levels of induction do not correlate with radiosensitivity as measured by cell survival assays. Rejoining of DSBs after doses in the range of 0-50 Gy was followed for 0, 15, 30, 60 and 120 min. We found a difference in the velocity of repair during the first hour after irradiation which is parallel to the differences in radiosensitivity. Thus U-1810 cells exhibit a fast component of repair, with about half of the DSBs being rejoined during the first 15 min, whereas U-1285 cells lack such a fast component, with only about 5% of the DSBs being rejoined after the same time. In addition there was a numerical albeit not statistical difference at 120 min, with more residual DSBs in the U-1285 cells compared to the U-1810 cells." @default.
- W2069202398 created "2016-06-24" @default.
- W2069202398 creator A5021072934 @default.
- W2069202398 creator A5071534778 @default.
- W2069202398 creator A5087206674 @default.
- W2069202398 creator A5026182786 @default.
- W2069202398 date "1994-07-01" @default.
- W2069202398 modified "2023-10-01" @default.
- W2069202398 title "Less Initial Rejoining of X-Ray-Induced DNA Double-Strand Breaks in Cells of a Small Cell (U-1285) Compared to a Large Cell (U-1810) Lung Carcinoma Cell Line" @default.
- W2069202398 cites W1653892452 @default.
- W2069202398 cites W1853436903 @default.
- W2069202398 cites W1967725400 @default.
- W2069202398 cites W1968352315 @default.
- W2069202398 cites W1968599965 @default.
- W2069202398 cites W1980697196 @default.
- W2069202398 cites W1993665683 @default.
- W2069202398 cites W1998372019 @default.
- W2069202398 cites W1999035626 @default.
- W2069202398 cites W2002010821 @default.
- W2069202398 cites W2004498595 @default.
- W2069202398 cites W2022929617 @default.
- W2069202398 cites W2023676537 @default.
- W2069202398 cites W2038889579 @default.
- W2069202398 cites W2044442979 @default.
- W2069202398 cites W2045313863 @default.
- W2069202398 cites W2052753490 @default.
- W2069202398 cites W2055523214 @default.
- W2069202398 cites W2059297853 @default.
- W2069202398 cites W2062456916 @default.
- W2069202398 cites W2069914850 @default.
- W2069202398 cites W2070745878 @default.
- W2069202398 cites W2071287201 @default.
- W2069202398 cites W2072845369 @default.
- W2069202398 cites W2077693350 @default.
- W2069202398 cites W2081566809 @default.
- W2069202398 cites W2089055554 @default.
- W2069202398 cites W2117591057 @default.
- W2069202398 cites W2135823194 @default.
- W2069202398 cites W2138460414 @default.
- W2069202398 cites W2330928819 @default.
- W2069202398 doi "https://doi.org/10.2307/3578729" @default.
- W2069202398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8016305" @default.
- W2069202398 hasPublicationYear "1994" @default.
- W2069202398 type Work @default.
- W2069202398 sameAs 2069202398 @default.
- W2069202398 citedByCount "17" @default.
- W2069202398 countsByYear W20692023982012 @default.
- W2069202398 countsByYear W20692023982013 @default.
- W2069202398 crossrefType "journal-article" @default.
- W2069202398 hasAuthorship W2069202398A5021072934 @default.
- W2069202398 hasAuthorship W2069202398A5026182786 @default.
- W2069202398 hasAuthorship W2069202398A5071534778 @default.
- W2069202398 hasAuthorship W2069202398A5087206674 @default.
- W2069202398 hasConcept C111337013 @default.
- W2069202398 hasConcept C121332964 @default.
- W2069202398 hasConcept C1491633281 @default.
- W2069202398 hasConcept C153911025 @default.
- W2069202398 hasConcept C185544564 @default.
- W2069202398 hasConcept C206684579 @default.
- W2069202398 hasConcept C2777546739 @default.
- W2069202398 hasConcept C502942594 @default.
- W2069202398 hasConcept C54355233 @default.
- W2069202398 hasConcept C552990157 @default.
- W2069202398 hasConcept C81885089 @default.
- W2069202398 hasConcept C86803240 @default.
- W2069202398 hasConceptScore W2069202398C111337013 @default.
- W2069202398 hasConceptScore W2069202398C121332964 @default.
- W2069202398 hasConceptScore W2069202398C1491633281 @default.
- W2069202398 hasConceptScore W2069202398C153911025 @default.
- W2069202398 hasConceptScore W2069202398C185544564 @default.
- W2069202398 hasConceptScore W2069202398C206684579 @default.
- W2069202398 hasConceptScore W2069202398C2777546739 @default.
- W2069202398 hasConceptScore W2069202398C502942594 @default.
- W2069202398 hasConceptScore W2069202398C54355233 @default.
- W2069202398 hasConceptScore W2069202398C552990157 @default.
- W2069202398 hasConceptScore W2069202398C81885089 @default.
- W2069202398 hasConceptScore W2069202398C86803240 @default.
- W2069202398 hasIssue "1" @default.
- W2069202398 hasLocation W20692023981 @default.
- W2069202398 hasLocation W20692023982 @default.
- W2069202398 hasOpenAccess W2069202398 @default.
- W2069202398 hasPrimaryLocation W20692023981 @default.
- W2069202398 hasRelatedWork W1976810488 @default.
- W2069202398 hasRelatedWork W2004549053 @default.
- W2069202398 hasRelatedWork W2015581780 @default.
- W2069202398 hasRelatedWork W2147582324 @default.
- W2069202398 hasRelatedWork W227681897 @default.
- W2069202398 hasRelatedWork W2394297438 @default.
- W2069202398 hasRelatedWork W2412649087 @default.
- W2069202398 hasRelatedWork W3160001410 @default.
- W2069202398 hasRelatedWork W3162217515 @default.
- W2069202398 hasRelatedWork W649607044 @default.
- W2069202398 hasVolume "139" @default.
- W2069202398 isParatext "false" @default.
- W2069202398 isRetracted "false" @default.
- W2069202398 magId "2069202398" @default.
- W2069202398 workType "article" @default.