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- W2069203431 abstract "T cell development and selection in the thymus are shaped by the induction of apoptosis. However, a direct role in T cell development and selection for any of the molecules known to regulate apoptosis has remained controversial. We have studied the effect of bax and bcl-2 transgenes in recombination activation gene 1–deficient (RAG-1−/−) mice transgenic for the major histocompatibility complex class I–restricted F5 T cell receptor. Overexpression of a bax transgene in the thymus seriously impairs the production of mature T cells, whereas bcl-2 overexpression greatly promotes it. The effect of bax and bcl-2 overexpression on antigen-induced negative selection was studied using fetal thymic organ cultures. This analysis showed that Bcl-2 strongly inhibits negative selection, whereas Bax does not affect it. Our data directly show that Bcl-2 family members have specific roles in T cell selection and also lend support to the hypothesis that Bax and Bcl-2 can antagonize each other's action in a certain apoptosis pathway while in another they can be functionally nonreciprocal." @default.
- W2069203431 created "2016-06-24" @default.
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- W2069203431 date "1998-09-21" @default.
- W2069203431 modified "2023-09-25" @default.
- W2069203431 title "The Action of Bax and Bcl-2 on T Cell Selection" @default.
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- W2069203431 doi "https://doi.org/10.1084/jem.188.6.1125" @default.
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