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- W2069211648 abstract "Allospecific T cells are known to play a central role in the process of allograft rejection. Recently, it has been shown that T cell function could be specifically targeted using DNA vaccination. In our model, PCR analysis of the TCR-β chain repertoire of T cells infiltrating rejected allografts showed specific expansions of the Vβ13 and Vβ2 families. In this study, we tested the effect on allograft survival of DNA vaccination against a specific TCR Vβ, in a model of heart allograft rejection in adult rats. Our results showed that anti-TCR Vβ13 DNA vaccination lead to a significant prolongation of allograft survival compared to vaccination against other Vβ families or untreated recipients. The prolongation of allograft survival correlated in vitro with a decrease in anti-donor reactivity of spleen cells from Vβ13-vaccinated rats. These results show that, in a transplantation model, DNA vaccination could be used as a method to specifically manipulate a T cell response and thus prolong allograft survival." @default.
- W2069211648 created "2016-06-24" @default.
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- W2069211648 date "2000-09-01" @default.
- W2069211648 modified "2023-09-25" @default.
- W2069211648 title "Anti-TCR Vβ-specific DNA vaccination prolongs heart allograft survival in adult rats" @default.
- W2069211648 doi "https://doi.org/10.1002/1521-4141(200009)30:9<2460::aid-immu2460>3.0.co;2-u" @default.
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