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- W2069226880 endingPage "1632" @default.
- W2069226880 startingPage "1621" @default.
- W2069226880 abstract "Urinary tract obstruction results in obstructive nephropathy and uropathy. It is the most frequent cause of renal failure in infants and children. In the past two decades studies of transgenic models and humans have greatly enhanced our understanding of the genetic factors and developmental processes important in urinary tract obstruction. The emerging picture is that development of the urinary tract requires precise integration of a variety of progenitor cell populations of different embryonic origins. Such integration is controlled by an intricate signaling network that undergoes dynamic changes as the embryo develops. Most congenital forms of urinary tract obstruction result from the disruption of diverse factors and genetic pathways involved in these processes, especially in the morphogenesis of the urinary conduit or the functional aspects of the pyeloureteral peristaltic machinery." @default.
- W2069226880 created "2016-06-24" @default.
- W2069226880 creator A5021979312 @default.
- W2069226880 date "2009-09-01" @default.
- W2069226880 modified "2023-10-13" @default.
- W2069226880 title "Genetic and developmental basis for urinary tract obstruction" @default.
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- W2069226880 doi "https://doi.org/10.1007/s00467-008-1072-y" @default.