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- W2069231874 abstract "In clarifying the possible involvement of cyclic AMP (cAMP) in prostaglandin (PG) E2-induced sensitization of the bradykinin response of canine testicular polymodal receptors, the effects of forskolin, an activator of adenylylcyclase, were studied in the presence and absence of acetylsalicylic acid (ASA, 550 μM) which blocks PG production. Forskolin (10 μM) seldom induced discharges in polymodal receptors. An unexpected outcome of this study was that forskolin induced no facilitation of the bradykinin (0.1 μM) response, both in the absence and presence of ASA. A slight yet significant suppression of the bradykinin response was instead observed in the absence of ASA. These results suggest that intracellular cAMP may be related with PG E2-induced sensitization of the bradykinin response through its decrease." @default.
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- W2069231874 date "1994-01-01" @default.
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- W2069231874 title "Forskolin does not augment the bradykinin response of canine visceral polymodal receptors in vitro" @default.
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- W2069231874 doi "https://doi.org/10.1016/0304-3940(94)90484-7" @default.
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