FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069245768> ?p ?o ?g. }

• W2069245768 abstract "Discussion • Sodium currents were measured from L5 pyramidal neurons using six stimulation protocols in the nucleated and outside-out configurations of the patch-clamp technique and fit to several kinetic models of voltage-gated sodium channels. • Out of a dozen voltage-gated sodium channel (VGSC) models (only relevant configurations shown) it appears that the most simplified, a four-state-16-parameter, Hidden-Markov-Model (HMM) provides the best fit for the data. • The ability of the chosen HMM model to simulate generation and propagation of action potentials (APs) in L5 pyramidal neurons was tested relative to the most prevalent and complete model of morphological influence on firing pattern. • The combination of the simplified HMM and a Hodgkin-Huxley-like voltage-gated potassium channel model provides the best simile of high frequency bursts of APs in L5 pyramidal neurons. • Further development and investigation of an adequate voltage-gated potassium channel HMM is needed to replace the HH paradigm. • The chosen HMM should be further tested on other types of VGSCs from various neurons and compared to the performance of other HMM. Figure 1: Fitting Newly Devised Models to Experimentally Recorded Voltage-Gated Na+ Channels Currents from neocortical pyramidal neurons –results of fitting a data set containing five pulse protocols to the kinetic model formalisms shown in the insets. A, A 16 kinetic parameters model consisting of two closed states, an open state and an inactivated state, with the maximal conductance of each protocol providing an extra parameter. The transition rate functions were defined as kij=aij.ezij .Vm and kji=aji.e-zji .Vm for i<j. B, An example of the fit achieved by the model shown in A to activation traces consisting of inward currents recorded in the nucleated configuration of the patch-clamp technique that were produced by a 100 ms pre-pulse to -130 mV followed by a 20 ms pulse to voltages between -130 to -25 mV at 5 mV increments. C, A 32 kinetic parameters model consisting of three closed states, an open state and two inactivated states, the maximal conductances and transition rate functions were included as in A. D, The same data as in B fit with the model shown in C. 1 ms 100 pA B" @default.
• W2069245768 created "2016-06-24" @default.
• W2069245768 creator A5022914884 @default.
• W2069245768 creator A5023610342 @default.
• W2069245768 date "2009-07-13" @default.
• W2069245768 modified "2023-09-26" @default.
• W2069245768 title "Modeling action potential initiation using voltage-gated ion-channels kinetics from L5 pyramidal neurons of the rat cortex" @default.
• W2069245768 doi "https://doi.org/10.1186/1471-2202-10-s1-p36" @default.
• W2069245768 hasPublicationYear "2009" @default.
• W2069245768 type Work @default.
• W2069245768 sameAs 2069245768 @default.
• W2069245768 citedByCount "0" @default.
• W2069245768 crossrefType "journal-article" @default.
• W2069245768 hasAuthorship W2069245768A5022914884 @default.
• W2069245768 hasAuthorship W2069245768A5023610342 @default.
• W2069245768 hasBestOaLocation W20692457681 @default.
• W2069245768 hasConcept C12554922 @default.
• W2069245768 hasConcept C169760540 @default.
• W2069245768 hasConcept C170493617 @default.
• W2069245768 hasConcept C185592680 @default.
• W2069245768 hasConcept C2777348757 @default.
• W2069245768 hasConcept C2778437258 @default.
• W2069245768 hasConcept C2781161787 @default.
• W2069245768 hasConcept C37088560 @default.
• W2069245768 hasConcept C41008148 @default.
• W2069245768 hasConcept C50254741 @default.
• W2069245768 hasConcept C55493867 @default.
• W2069245768 hasConcept C86803240 @default.
• W2069245768 hasConceptScore W2069245768C12554922 @default.
• W2069245768 hasConceptScore W2069245768C169760540 @default.
• W2069245768 hasConceptScore W2069245768C170493617 @default.
• W2069245768 hasConceptScore W2069245768C185592680 @default.
• W2069245768 hasConceptScore W2069245768C2777348757 @default.
• W2069245768 hasConceptScore W2069245768C2778437258 @default.
• W2069245768 hasConceptScore W2069245768C2781161787 @default.
• W2069245768 hasConceptScore W2069245768C37088560 @default.
• W2069245768 hasConceptScore W2069245768C41008148 @default.
• W2069245768 hasConceptScore W2069245768C50254741 @default.
• W2069245768 hasConceptScore W2069245768C55493867 @default.
• W2069245768 hasConceptScore W2069245768C86803240 @default.
• W2069245768 hasIssue "S1" @default.
• W2069245768 hasLocation W20692457681 @default.
• W2069245768 hasOpenAccess W2069245768 @default.
• W2069245768 hasPrimaryLocation W20692457681 @default.
• W2069245768 hasRelatedWork W159622387 @default.
• W2069245768 hasRelatedWork W2033259519 @default.
• W2069245768 hasRelatedWork W2279398309 @default.
• W2069245768 hasRelatedWork W2304255651 @default.
• W2069245768 hasRelatedWork W2484102871 @default.
• W2069245768 hasRelatedWork W2492978174 @default.
• W2069245768 hasRelatedWork W3023541640 @default.
• W2069245768 hasRelatedWork W331524620 @default.
• W2069245768 hasRelatedWork W4230117471 @default.
• W2069245768 hasRelatedWork W73308090 @default.
• W2069245768 hasVolume "10" @default.
• W2069245768 isParatext "false" @default.
• W2069245768 isRetracted "false" @default.
• W2069245768 magId "2069245768" @default.
• W2069245768 workType "article" @default.