FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069260057> ?p ?o ?g. }

• W2069260057 endingPage "161" @default.
• W2069260057 startingPage "154" @default.
• W2069260057 abstract "Background and Purpose —It has been suggested that mitogen-activated protein kinase (MAPK) is involved in cerebral vasospasm after subarachnoid hemorrhage. The present study was undertaken to explore the inhibitory effect of U0126, a novel MAPK inhibitor, in the contraction of the rabbit basilar artery by 3 spasmogens: hemolysate, oxyhemoglobin, and bloody cerebrospinal fluid (CSF) from patients with vasospasm. Methods —The contraction and relaxation of rabbit basilar arteries were measured by isometric tension. MAPK immunoprecipitation was assessed by Western blot analysis. Results —(1) Pretreatment of the rabbit basilar arteries with U0126 reduced contractions to hemolysate, oxyhemoglobin, or bloody CSF applied subsequently. (2) In the absence of endothelial cells, U0126 produced an inhibitory effect similar to the contractions induced by hemolysate, oxyhemoglobin, or bloody CSF. (3) U0126 relaxed the sustained contraction induced by hemolysate, oxyhemoglobin, or bloody CSF. (4) Hemolysate, oxyhemoglobin, and bloody CSF enhanced MAPK immunoprecipitation. (5) U0126 reduced MAPK immunoprecipitation induced by hemolysate, oxyhemoglobin, and bloody CSF. (6) Hemolysate, oxyhemoglobin, and bloody CSF significantly increased MAPK activity in the rabbit basilar artery. (7) U0126 abolished the effect of hemolysate, oxyhemoglobin, or bloody CSF on MAPK activation. Conclusions —This study demonstrated a role of MAPK in the contraction of rabbit basilar arteries by hemolysate, oxyhemoglobin, and bloody CSF. MAPK inhibitor U0126 may be useful in the treatment of cerebral vasospasm." @default.
• W2069260057 created "2016-06-24" @default.
• W2069260057 creator A5016467704 @default.
• W2069260057 creator A5019936651 @default.
• W2069260057 creator A5032152839 @default.
• W2069260057 creator A5056379473 @default.
• W2069260057 creator A5081813934 @default.
• W2069260057 date "2001-01-01" @default.
• W2069260057 modified "2023-09-26" @default.
• W2069260057 title "Relaxant Effect of U0126 in Hemolysate-, Oxyhemoglobin-, and Bloody Cerebrospinal Fluid–Induced Contraction in Rabbit Basilar Artery" @default.
• W2069260057 cites W1577814279 @default.
• W2069260057 cites W1967501517 @default.
• W2069260057 cites W1985960247 @default.
• W2069260057 cites W1989226644 @default.
• W2069260057 cites W2003676033 @default.
• W2069260057 cites W2004455838 @default.
• W2069260057 cites W2023929613 @default.
• W2069260057 cites W2036176695 @default.
• W2069260057 cites W2037899846 @default.
• W2069260057 cites W2045675634 @default.
• W2069260057 cites W2055990050 @default.
• W2069260057 cites W2064865425 @default.
• W2069260057 cites W2075204296 @default.
• W2069260057 cites W2076744300 @default.
• W2069260057 cites W2086262311 @default.
• W2069260057 cites W2087342222 @default.
• W2069260057 cites W2089443046 @default.
• W2069260057 cites W2094034862 @default.
• W2069260057 cites W2396658198 @default.
• W2069260057 cites W2426867356 @default.
• W2069260057 cites W34289836 @default.
• W2069260057 doi "https://doi.org/10.1161/01.str.32.1.154" @default.
• W2069260057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11136931" @default.
• W2069260057 hasPublicationYear "2001" @default.
• W2069260057 type Work @default.
• W2069260057 sameAs 2069260057 @default.
• W2069260057 citedByCount "25" @default.
• W2069260057 countsByYear W20692600572012 @default.
• W2069260057 countsByYear W20692600572013 @default.
• W2069260057 countsByYear W20692600572014 @default.
• W2069260057 countsByYear W20692600572015 @default.
• W2069260057 countsByYear W20692600572016 @default.
• W2069260057 crossrefType "journal-article" @default.
• W2069260057 hasAuthorship W2069260057A5016467704 @default.
• W2069260057 hasAuthorship W2069260057A5019936651 @default.
• W2069260057 hasAuthorship W2069260057A5032152839 @default.
• W2069260057 hasAuthorship W2069260057A5056379473 @default.
• W2069260057 hasAuthorship W2069260057A5081813934 @default.
• W2069260057 hasBestOaLocation W20692600571 @default.
• W2069260057 hasConcept C126322002 @default.
• W2069260057 hasConcept C134018914 @default.
• W2069260057 hasConcept C141071460 @default.
• W2069260057 hasConcept C163415756 @default.
• W2069260057 hasConcept C171614378 @default.
• W2069260057 hasConcept C184235292 @default.
• W2069260057 hasConcept C2776820941 @default.
• W2069260057 hasConcept C2777736543 @default.
• W2069260057 hasConcept C2778506911 @default.
• W2069260057 hasConcept C2779576792 @default.
• W2069260057 hasConcept C2779651940 @default.
• W2069260057 hasConcept C2779961880 @default.
• W2069260057 hasConcept C2781012200 @default.
• W2069260057 hasConcept C42219234 @default.
• W2069260057 hasConcept C55493867 @default.
• W2069260057 hasConcept C57074206 @default.
• W2069260057 hasConcept C71924100 @default.
• W2069260057 hasConcept C86803240 @default.
• W2069260057 hasConceptScore W2069260057C126322002 @default.
• W2069260057 hasConceptScore W2069260057C134018914 @default.
• W2069260057 hasConceptScore W2069260057C141071460 @default.
• W2069260057 hasConceptScore W2069260057C163415756 @default.
• W2069260057 hasConceptScore W2069260057C171614378 @default.
• W2069260057 hasConceptScore W2069260057C184235292 @default.
• W2069260057 hasConceptScore W2069260057C2776820941 @default.
• W2069260057 hasConceptScore W2069260057C2777736543 @default.
• W2069260057 hasConceptScore W2069260057C2778506911 @default.
• W2069260057 hasConceptScore W2069260057C2779576792 @default.
• W2069260057 hasConceptScore W2069260057C2779651940 @default.
• W2069260057 hasConceptScore W2069260057C2779961880 @default.
• W2069260057 hasConceptScore W2069260057C2781012200 @default.
• W2069260057 hasConceptScore W2069260057C42219234 @default.
• W2069260057 hasConceptScore W2069260057C55493867 @default.
• W2069260057 hasConceptScore W2069260057C57074206 @default.
• W2069260057 hasConceptScore W2069260057C71924100 @default.
• W2069260057 hasConceptScore W2069260057C86803240 @default.
• W2069260057 hasIssue "1" @default.
• W2069260057 hasLocation W20692600571 @default.
• W2069260057 hasLocation W20692600572 @default.
• W2069260057 hasOpenAccess W2069260057 @default.
• W2069260057 hasPrimaryLocation W20692600571 @default.
• W2069260057 hasRelatedWork W1970861914 @default.
• W2069260057 hasRelatedWork W1973166377 @default.
• W2069260057 hasRelatedWork W2011013688 @default.
• W2069260057 hasRelatedWork W2023707548 @default.
• W2069260057 hasRelatedWork W2029327983 @default.
• W2069260057 hasRelatedWork W2038428557 @default.
• W2069260057 hasRelatedWork W2081976643 @default.
• W2069260057 hasRelatedWork W2088123978 @default.

• next