Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069263382> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2069263382 abstract "Although arsenic trioxide (As2O3) has been successfully employed in treatment of patients with APL (acute promyelocytic leukemia), the sensitivity of solid tumor cells to this treatment was much lower than APL cells. The single agent of As2O3 was inefficient for treatment of hepatocellular carcinoma (HCC) in phase II trial demonstrating that new modalities of treatment with enhanced therapeutic effect are needed. In this study, we showed that oridonin, a diterpenoid isolated from traditional Chinese medicine Rabdosia rubescences, greatly potentiated apoptosis induced by As2O3 in hepatocellular carcinoma cells. The synergistic pro-apoptosis effect of combination of these two drugs led to increase in intracellular reactive oxygen species (ROS) level and N-acetyl-L-cysteine (NAC), a thiol-containing anti-oxidant, was able to completely block the effect. The combination treatment induced ROS-dependent decrease in mitochondrial membrane potential (MMP) decrease, and relocation of Bax and cytochrome C. Besides, oridonin dramatically increased the intracellular Ca2+ overload triggered by As2O3. Furthermore, the co-treatment of oridonin and As2O3 induced ROS-mediated down-regulation of Akt and XIAP, and inhibition of NF-κB activation. The two drug combination enhanced tumor suppression activity in murine HCC model compared with single agent treatment in vivo. These findings demonstrate that oridonin can sensitize hepatocellular carcinoma cells to As2O3 treatment and will facilitate the optimization of As2O3 therapy for HCC patients." @default.
- W2069263382 created "2016-06-24" @default.
- W2069263382 creator A5039358700 @default.
- W2069263382 date "2011-09-22" @default.
- W2069263382 modified "2023-09-30" @default.
- W2069263382 title "Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells" @default.
- W2069263382 doi "https://doi.org/10.3892/ijo.2011.1210" @default.
- W2069263382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21947421" @default.
- W2069263382 hasPublicationYear "2011" @default.
- W2069263382 type Work @default.
- W2069263382 sameAs 2069263382 @default.
- W2069263382 citedByCount "24" @default.
- W2069263382 countsByYear W20692633822013 @default.
- W2069263382 countsByYear W20692633822014 @default.
- W2069263382 countsByYear W20692633822015 @default.
- W2069263382 countsByYear W20692633822016 @default.
- W2069263382 countsByYear W20692633822017 @default.
- W2069263382 countsByYear W20692633822019 @default.
- W2069263382 countsByYear W20692633822020 @default.
- W2069263382 countsByYear W20692633822021 @default.
- W2069263382 crossrefType "journal-article" @default.
- W2069263382 hasAuthorship W2069263382A5039358700 @default.
- W2069263382 hasBestOaLocation W20692633821 @default.
- W2069263382 hasConcept C104317684 @default.
- W2069263382 hasConcept C185592680 @default.
- W2069263382 hasConcept C190283241 @default.
- W2069263382 hasConcept C2776601000 @default.
- W2069263382 hasConcept C2776999253 @default.
- W2069263382 hasConcept C2778019345 @default.
- W2069263382 hasConcept C2780386689 @default.
- W2069263382 hasConcept C2781121885 @default.
- W2069263382 hasConcept C31573885 @default.
- W2069263382 hasConcept C33195913 @default.
- W2069263382 hasConcept C48349386 @default.
- W2069263382 hasConcept C502942594 @default.
- W2069263382 hasConcept C55493867 @default.
- W2069263382 hasConcept C71924100 @default.
- W2069263382 hasConcept C98274493 @default.
- W2069263382 hasConcept C98424977 @default.
- W2069263382 hasConceptScore W2069263382C104317684 @default.
- W2069263382 hasConceptScore W2069263382C185592680 @default.
- W2069263382 hasConceptScore W2069263382C190283241 @default.
- W2069263382 hasConceptScore W2069263382C2776601000 @default.
- W2069263382 hasConceptScore W2069263382C2776999253 @default.
- W2069263382 hasConceptScore W2069263382C2778019345 @default.
- W2069263382 hasConceptScore W2069263382C2780386689 @default.
- W2069263382 hasConceptScore W2069263382C2781121885 @default.
- W2069263382 hasConceptScore W2069263382C31573885 @default.
- W2069263382 hasConceptScore W2069263382C33195913 @default.
- W2069263382 hasConceptScore W2069263382C48349386 @default.
- W2069263382 hasConceptScore W2069263382C502942594 @default.
- W2069263382 hasConceptScore W2069263382C55493867 @default.
- W2069263382 hasConceptScore W2069263382C71924100 @default.
- W2069263382 hasConceptScore W2069263382C98274493 @default.
- W2069263382 hasConceptScore W2069263382C98424977 @default.
- W2069263382 hasLocation W20692633821 @default.
- W2069263382 hasLocation W20692633822 @default.
- W2069263382 hasOpenAccess W2069263382 @default.
- W2069263382 hasPrimaryLocation W20692633821 @default.
- W2069263382 hasRelatedWork W1963777790 @default.
- W2069263382 hasRelatedWork W2010432253 @default.
- W2069263382 hasRelatedWork W2124549709 @default.
- W2069263382 hasRelatedWork W2171522243 @default.
- W2069263382 hasRelatedWork W2363795304 @default.
- W2069263382 hasRelatedWork W2375686485 @default.
- W2069263382 hasRelatedWork W2387907076 @default.
- W2069263382 hasRelatedWork W2406878689 @default.
- W2069263382 hasRelatedWork W2979977041 @default.
- W2069263382 hasRelatedWork W3151819429 @default.
- W2069263382 isParatext "false" @default.
- W2069263382 isRetracted "false" @default.
- W2069263382 magId "2069263382" @default.
- W2069263382 workType "article" @default.