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• W2069267029 abstract "1 Pantetheinephosphate adenylyltransferase and dephospho-CoA kinase, which are last in the sequence leading to the biosynthesis of CoA, are localized in mitochondria (about 30% of the activity in the cell) and cytosol. The first three enzymes in the pathway are only found in cytosol [Skrede, S. and Halvorsen, O. (1979) Biochem. Biophys. Res. Commun. 91, 1536–1542]. 2 Both enzymes are present in the mitochondrial matrix, but dephospho-CoA kinase also has a more ‘external’ pool and is less easily removed from the membrane fractions of the mitochondria. 3 In accordance with the submitochondrial fractionation studies, pantetheinephosphate adenylyltransferase is to a larger extent activated by detergents or mechanical disruption of the mitochondria than is dephospho-CoA kinase. 4 In intact mitochondria, the biosynthesis of CoA from 4-phosphopantetheine was stimulated by uncoupling agents, probably because of facilitated penetration of the substrate through the inner mitochondrial membrane and or of leakage of a regulator. 5 Intact mitochondria could increase the synthesis of CoA 5–10 times, when conditions were chosen to promote biosynthesis from 4-phosphopantetheine and to remove CoA by acylation and/or ‘leakage’ out of the mitochondria. 6 The kinetic properties of both mitochondrial enzymes are quite similar to the cytosolic ones (but our reinvestigation of the latter enzymes only partially confirm previous studies). Km for 4-phosphopantetheine and dephosplio-CoA were 0.015 and 0.01 mmol/1, respectively, for the mitochondrial enzymes. 7 Mitochondrial biosynthesis of CoA was strongly inhibited by dephospho-CoA at the pantetheinephosphate adenylyltransferase level and more slightly by CoA at the dephospho-CoA kinase level" @default.
• W2069267029 created "2016-06-24" @default.
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• W2069267029 date "1983-03-01" @default.
• W2069267029 modified "2023-10-11" @default.
• W2069267029 title "Mitochondrial Pantetheinephosphate Adenylyltransferase and Dephospho-CoA Kinase" @default.
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• W2069267029 doi "https://doi.org/10.1111/j.1432-1033.1983.tb07231.x" @default.
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