FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069270633> ?p ?o ?g. }

• W2069270633 endingPage "199" @default.
• W2069270633 startingPage "194" @default.
• W2069270633 abstract "The stimulation of cell proliferation by insulin like growth factor IGF-1 has previously been shown to depend on activation of voltage gated K(+) channels. The signaling involved in activation of voltage gated K(+) channel Kv1.3 includes the phosphatidylinositol-3 (PI3) protein kinase, 3-phosphoinositide dependent protein kinase PDK1 and the serum and glucocorticoid inducible kinase SGK1. However, nothing is known about mechanisms mediating the stimulation of Kv1.3 by SGK1. Most recently, SGK1 has been shown to phosphorylate and thus inactivate the ubiquitin ligase Nedd4-2. The present study has been performed to explore whether the regulation of Kv1.3 involves Nedd4-2. To this end Kv1.3 has been expressed in Xenopus oocytes with or without coexpression of Nedd4-2 and/or constitutively active (S422D)SGK1. In oocytes expressing Kv1.3 but not in water injected oocytes, depolarization from a holding potential of -80 mV to +20 mV triggers rapidly inactivating currents typical for Kv1.3. Coexpression of Nedd4-2 decreases, coexpression of (S422D)SGK1 enhances the currents significantly. The effects of either Nedd4-2 or of SGK1 are abrogated by destruction of the respective catalytic subunits ((C938S)Nedd4-2 or (K127N)SGK1). Further experiments revealed that wild type SGK1 and SGK3 and to a lesser extent SGK2 are similarly effective in stimulating Kv1.3 in both, presence and absence of Nedd4-2. It is concluded that Kv1.3 is downregulated by Nedd4-2 and stimulates by SGK1, SGK2, and SGK3. The data thus disclose a novel mechanism of Kv1.3 channel regulation." @default.
• W2069270633 created "2016-06-24" @default.
• W2069270633 creator A5033729491 @default.
• W2069270633 creator A5055172655 @default.
• W2069270633 creator A5070018965 @default.
• W2069270633 creator A5071851806 @default.
• W2069270633 creator A5084208566 @default.
• W2069270633 date "2003-11-10" @default.
• W2069270633 modified "2023-10-15" @default.
• W2069270633 title "Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1" @default.
• W2069270633 cites W145792665 @default.
• W2069270633 cites W1531851959 @default.
• W2069270633 cites W1544175192 @default.
• W2069270633 cites W1677916325 @default.
• W2069270633 cites W170591362 @default.
• W2069270633 cites W1726025741 @default.
• W2069270633 cites W1964385546 @default.
• W2069270633 cites W1964495268 @default.
• W2069270633 cites W1969213411 @default.
• W2069270633 cites W1970548320 @default.
• W2069270633 cites W1981460409 @default.
• W2069270633 cites W1982991759 @default.
• W2069270633 cites W1985854246 @default.
• W2069270633 cites W1993835711 @default.
• W2069270633 cites W1993855694 @default.
• W2069270633 cites W1997986332 @default.
• W2069270633 cites W2004947583 @default.
• W2069270633 cites W2005729567 @default.
• W2069270633 cites W2008169189 @default.
• W2069270633 cites W2011297406 @default.
• W2069270633 cites W2020437259 @default.
• W2069270633 cites W2021085051 @default.
• W2069270633 cites W2021434619 @default.
• W2069270633 cites W2043664888 @default.
• W2069270633 cites W2048653590 @default.
• W2069270633 cites W2051420203 @default.
• W2069270633 cites W2052592595 @default.
• W2069270633 cites W2054366295 @default.
• W2069270633 cites W2055671120 @default.
• W2069270633 cites W2070864725 @default.
• W2069270633 cites W2076370506 @default.
• W2069270633 cites W2089031022 @default.
• W2069270633 cites W2091317282 @default.
• W2069270633 cites W2097923714 @default.
• W2069270633 cites W2100126797 @default.
• W2069270633 cites W2104183234 @default.
• W2069270633 cites W2121806269 @default.
• W2069270633 cites W2124097655 @default.
• W2069270633 cites W2124954761 @default.
• W2069270633 cites W2136901254 @default.
• W2069270633 cites W2141578443 @default.
• W2069270633 cites W2144072685 @default.
• W2069270633 cites W2147906559 @default.
• W2069270633 cites W2151752218 @default.
• W2069270633 cites W2154782902 @default.
• W2069270633 cites W2162193671 @default.
• W2069270633 cites W2167816721 @default.
• W2069270633 cites W2169494292 @default.
• W2069270633 cites W2338061499 @default.
• W2069270633 cites W2340533989 @default.
• W2069270633 cites W2469938121 @default.
• W2069270633 cites W7405620 @default.
• W2069270633 doi "https://doi.org/10.1002/jcp.10430" @default.
• W2069270633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15040001" @default.
• W2069270633 hasPublicationYear "2003" @default.
• W2069270633 type Work @default.
• W2069270633 sameAs 2069270633 @default.
• W2069270633 citedByCount "96" @default.
• W2069270633 countsByYear W20692706332012 @default.
• W2069270633 countsByYear W20692706332013 @default.
• W2069270633 countsByYear W20692706332014 @default.
• W2069270633 countsByYear W20692706332015 @default.
• W2069270633 countsByYear W20692706332016 @default.
• W2069270633 countsByYear W20692706332017 @default.
• W2069270633 countsByYear W20692706332019 @default.
• W2069270633 countsByYear W20692706332020 @default.
• W2069270633 countsByYear W20692706332021 @default.
• W2069270633 countsByYear W20692706332023 @default.
• W2069270633 crossrefType "journal-article" @default.
• W2069270633 hasAuthorship W2069270633A5033729491 @default.
• W2069270633 hasAuthorship W2069270633A5055172655 @default.
• W2069270633 hasAuthorship W2069270633A5070018965 @default.
• W2069270633 hasAuthorship W2069270633A5071851806 @default.
• W2069270633 hasAuthorship W2069270633A5084208566 @default.
• W2069270633 hasConcept C104317684 @default.
• W2069270633 hasConcept C11960822 @default.
• W2069270633 hasConcept C134459356 @default.
• W2069270633 hasConcept C153911025 @default.
• W2069270633 hasConcept C184150571 @default.
• W2069270633 hasConcept C184235292 @default.
• W2069270633 hasConcept C185592680 @default.
• W2069270633 hasConcept C25602115 @default.
• W2069270633 hasConcept C2777265272 @default.
• W2069270633 hasConcept C2779535977 @default.
• W2069270633 hasConcept C2780610907 @default.
• W2069270633 hasConcept C55493867 @default.
• W2069270633 hasConcept C86803240 @default.
• W2069270633 hasConcept C95444343 @default.

• next