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- W2069271306 abstract "Haematopoietic cell kinase (Hck) is a protein tyrosine kinase of the Src family specifically expressed in phagocytes as two isoforms, p59Hck and p61Hck, present at the plasma membrane and lysosomes, respectively. We report that ectopic expression of a constitutively active mutant of p61Hck (p61Hck(ca)) triggered the de novo formation of actin-rich rings at the ventral face of the cells that we characterized as bona fide podosome rosettes, structures involved in cell migration. Their formation required the adaptor domains and the kinase activity of p61Hck, the integrity of microfilament and microtubule networks and concerted action of Cdc42, Rac and Rho. Podosome rosette formation was either abolished when p61Hck(ca) was readdressed from lysosomes to the cytosol or triggered when p59Hck(ca) was relocalized to lysosomes. Lysosomal markers were present at podosome rosettes. By stimulating exocytosis of p61Hck(ca) lysosomes with a calcium ionophore, the formation of podosome rosettes was enhanced. Interestingly, we confirm that, in human macrophages, Hck and lysosomal markers were present at podosomes which were spatially reorganized as clusters, a foregoing step to form rosettes, upon expression of p61Hck(ca). We propose that lysosomes, under the control of p61Hck, are involved in the biogenesis of podosomes, a key phenomenon in the migration of phagocytes." @default.
- W2069271306 created "2016-06-24" @default.
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- W2069271306 date "2005-06-09" @default.
- W2069271306 modified "2023-10-18" @default.
- W2069271306 title "Activation of the Lysosome‐Associated p61Hck Isoform Triggers the Biogenesis of Podosomes" @default.
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- W2069271306 cites W2170770186 @default.
- W2069271306 cites W2177733342 @default.
- W2069271306 cites W2281057788 @default.
- W2069271306 cites W2333011916 @default.
- W2069271306 cites W2333603867 @default.
- W2069271306 cites W2338151820 @default.
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- W2069271306 doi "https://doi.org/10.1111/j.1600-0854.2005.00307.x" @default.
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