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• W2069274680 startingPage "e67472" @default.
• W2069274680 abstract "The outcome of infection by Mycobacterium tuberculosis (Mtb) depends greatly on how the host responds to the bacteria and how the bacteria manipulates the host, which is facilitated by protein-protein interactions. Thus, to understand this process, there is a need for elucidating protein interactions between human and Mtb, which may enable us to characterize specific molecular mechanisms allowing the bacteria to persist and survive under different environmental conditions. In this work, we used the interologs method based on experimentally verified intra-species and inter-species interactions to predict human-Mtb functional interactions. These interactions were further filtered using known human-Mtb interactions and genes that are differentially expressed during infection, producing 190 interactions. Further analysis of the subcellular location of proteins involved in these human-Mtb interactions confirms feasibility of these interactions. We also conducted functional analysis of human and Mtb proteins involved in these interactions, checking whether these proteins play a role in infection and/or disease, and enriching Mtb proteins in a previously predicted list of drug targets. We found that the biological processes of the human interacting proteins suggested their involvement in apoptosis and production of nitric oxide, whereas those of the Mtb interacting proteins were relevant to the intracellular environment of Mtb in the host. Mapping these proteins onto KEGG pathways highlighted proteins belonging to the tuberculosis pathway and also suggested that Mtb proteins might use the host to acquire nutrients, which is in agreement with the intracellular lifestyle of Mtb. This indicates that these interactions can shed light on the interplay between Mtb and its human host and thus, contribute to the process of designing novel drugs with new biological mechanisms of action." @default.
• W2069274680 created "2016-06-24" @default.
• W2069274680 creator A5010575604 @default.
• W2069274680 creator A5062226758 @default.
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• W2069274680 date "2013-07-02" @default.
• W2069274680 modified "2023-10-17" @default.
• W2069274680 title "Predicting and Analyzing Interactions between Mycobacterium tuberculosis and Its Human Host" @default.
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• W2069274680 doi "https://doi.org/10.1371/journal.pone.0067472" @default.
• W2069274680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3699628" @default.
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• W2069274680 hasPublicationYear "2013" @default.
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