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- W2069294586 endingPage "2231" @default.
- W2069294586 startingPage "2216" @default.
- W2069294586 abstract "The vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pathophysiological conditions, including atherosclerosis, hypertension and diabetes. Patients with diabetes invariably show an impairment of endothelium-dependent vasodilation. Therefore, understanding and treating endothelial dysfunction is a major focus in the prevention of vascular complications associated with all forms of diabetes mellitus. The mechanisms of endothelial dysfunction in diabetes may point to new management strategies for the prevention of cardiovascular disease in diabetes. This review will focus on the mechanisms and therapeutics that specifically target endothelial dysfunction in the context of a diabetic setting. Mechanisms including altered glucose metabolism, impaired insulin signaling, low-grade inflammatory state, and increased reactive oxygen species generation will be discussed. The importance of developing new pharmacological approaches that upregulate endothelium-derived nitric oxide synthesis and target key vascular ROS-producing enzymes will be highlighted and new strategies that might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated vascular complications." @default.
- W2069294586 created "2016-06-24" @default.
- W2069294586 creator A5047487473 @default.
- W2069294586 creator A5070411081 @default.
- W2069294586 creator A5088899608 @default.
- W2069294586 date "2013-12-01" @default.
- W2069294586 modified "2023-10-10" @default.
- W2069294586 title "Endothelial dysfunction — A major mediator of diabetic vascular disease" @default.
- W2069294586 cites W103480297 @default.
- W2069294586 cites W1489379070 @default.
- W2069294586 cites W1499143025 @default.
- W2069294586 cites W1521905573 @default.
- W2069294586 cites W1528925569 @default.
- W2069294586 cites W1529592271 @default.
- W2069294586 cites W1537398036 @default.
- W2069294586 cites W156498367 @default.
- W2069294586 cites W1572193815 @default.
- W2069294586 cites W1671050155 @default.
- W2069294586 cites W1684778245 @default.
- W2069294586 cites W1736337862 @default.
- W2069294586 cites W1752614770 @default.
- W2069294586 cites W1816713267 @default.
- W2069294586 cites W1842179070 @default.
- W2069294586 cites W1856749732 @default.
- W2069294586 cites W1891967301 @default.
- W2069294586 cites W1896800875 @default.
- W2069294586 cites W1928175618 @default.
- W2069294586 cites W1963595012 @default.
- W2069294586 cites W1964799256 @default.
- W2069294586 cites W1965148671 @default.
- W2069294586 cites W1971510408 @default.
- W2069294586 cites W1971892871 @default.
- W2069294586 cites W1972891217 @default.
- W2069294586 cites W1973252400 @default.
- W2069294586 cites W1974997758 @default.
- W2069294586 cites W1975628529 @default.
- W2069294586 cites W1975969421 @default.
- W2069294586 cites W1977628398 @default.
- W2069294586 cites W1978241894 @default.
- W2069294586 cites W1978640785 @default.
- W2069294586 cites W1979356762 @default.
- W2069294586 cites W1980964357 @default.
- W2069294586 cites W1981265053 @default.
- W2069294586 cites W1981905227 @default.
- W2069294586 cites W1982575337 @default.
- W2069294586 cites W1983701023 @default.
- W2069294586 cites W1986364810 @default.
- W2069294586 cites W1988702757 @default.
- W2069294586 cites W1988711065 @default.
- W2069294586 cites W1988960591 @default.
- W2069294586 cites W1989245499 @default.
- W2069294586 cites W1989656393 @default.
- W2069294586 cites W1990811092 @default.
- W2069294586 cites W1992547254 @default.
- W2069294586 cites W1993921230 @default.
- W2069294586 cites W1996004260 @default.
- W2069294586 cites W1998369303 @default.
- W2069294586 cites W1999971397 @default.
- W2069294586 cites W2001418667 @default.
- W2069294586 cites W2003449292 @default.
- W2069294586 cites W2005040360 @default.
- W2069294586 cites W2005139390 @default.
- W2069294586 cites W2005566968 @default.
- W2069294586 cites W2006330191 @default.
- W2069294586 cites W2006847107 @default.
- W2069294586 cites W2007737411 @default.
- W2069294586 cites W2008684260 @default.
- W2069294586 cites W2012006860 @default.
- W2069294586 cites W2012185701 @default.
- W2069294586 cites W2013063627 @default.
- W2069294586 cites W2015174450 @default.
- W2069294586 cites W2016637704 @default.
- W2069294586 cites W2019514289 @default.
- W2069294586 cites W2020333559 @default.
- W2069294586 cites W2020764743 @default.
- W2069294586 cites W2021403302 @default.
- W2069294586 cites W2021783313 @default.
- W2069294586 cites W2022327273 @default.
- W2069294586 cites W2025679035 @default.
- W2069294586 cites W2026425756 @default.
- W2069294586 cites W2026944526 @default.
- W2069294586 cites W2029533353 @default.
- W2069294586 cites W2032361554 @default.
- W2069294586 cites W2032892013 @default.
- W2069294586 cites W2033656398 @default.
- W2069294586 cites W2033859994 @default.
- W2069294586 cites W2038965219 @default.
- W2069294586 cites W2039098094 @default.
- W2069294586 cites W2044437167 @default.
- W2069294586 cites W2045221177 @default.
- W2069294586 cites W2050601245 @default.
- W2069294586 cites W2051458463 @default.
- W2069294586 cites W2051526761 @default.
- W2069294586 cites W2052034057 @default.
- W2069294586 cites W2052894208 @default.
- W2069294586 cites W2057651652 @default.
- W2069294586 cites W2058693442 @default.
- W2069294586 cites W2059571803 @default.