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• W2069298424 abstract "Riboswitches are regions of mRNA that directly bind metabolites, leading to alteration of gene expression. We have developed fragment-based methods to screen for compounds that bind the Escherichia coli thiM riboswitch. Using complementary biophysical techniques we have identified several ligands with K(D) <100 microM. From these there is the potential to develop potent and selective modulators of riboswitch function." @default.
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• W2069298424 date "2010-02-25" @default.
• W2069298424 modified "2023-10-18" @default.
• W2069298424 title "A Fragment-Based Approach to Identifying Ligands for Riboswitches" @default.
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• W2069298424 doi "https://doi.org/10.1021/cb9003139" @default.
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