FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069311331> ?p ?o ?g. }

• W2069311331 endingPage "e27048" @default.
• W2069311331 startingPage "e27048" @default.
• W2069311331 abstract "Cortical GABAergic interneurons originate from ganglionic eminences and tangentially migrate into the cortical plate at early developmental stages. To elucidate the characteristics of this migration of GABAergic interneurons in living animals, we established an experimental design specialized for in vivo time-lapse imaging of the neocortex of neonate mice with two-photon laser-scanning microscopy. In vesicular GABA/glycine transporter (VGAT)-Venus transgenic mice from birth (P0) through P3, we observed multidirectional tangential migration of genetically-defined GABAergic interneurons in the neocortical marginal zone. The properties of this migration, such as the motility rate (distance/hr), the direction moved, and the proportion of migrating neurons to stationary neurons, did not change through P0 to P3, although the density of GABAergic neurons at the marginal zone decreased with age. Thus, the characteristics of the tangential motility of individual GABAergic neurons remained constant in development. Pharmacological block of GABAA receptors and of the Na+-K+-Cl− cotransporters, and chelating intracellular Ca2+, all significantly reduced the motility rate in vivo. The motility rate and GABA content within the cortex of neonatal VGAT-Venus transgenic mice were significantly greater than those of GAD67-GFP knock-in mice, suggesting that extracellular GABA concentration could facilitate the multidirectional tangential migration. Indeed, diazepam applied to GAD67-GFP mice increased the motility rate substantially. In an in vitro neocortical slice preparation, we confirmed that GABA induced a NKCC sensitive depolarization of GABAergic interneurons in VGAT-Venus mice at P0-P3. Thus, activation of GABAAR by ambient GABA depolarizes GABAergic interneurons, leading to an acceleration of their multidirectional motility in vivo." @default.
• W2069311331 created "2016-06-24" @default.
• W2069311331 creator A5012076614 @default.
• W2069311331 creator A5014321400 @default.
• W2069311331 creator A5016272404 @default.
• W2069311331 creator A5026068118 @default.
• W2069311331 creator A5026469672 @default.
• W2069311331 creator A5042956844 @default.
• W2069311331 creator A5048547119 @default.
• W2069311331 creator A5055208450 @default.
• W2069311331 creator A5081934281 @default.
• W2069311331 date "2011-12-13" @default.
• W2069311331 modified "2023-09-23" @default.
• W2069311331 title "GABA Regulates the Multidirectional Tangential Migration of GABAergic Interneurons in Living Neonatal Mice" @default.
• W2069311331 cites W1588629441 @default.
• W2069311331 cites W1626746097 @default.
• W2069311331 cites W1642675585 @default.
• W2069311331 cites W1856380311 @default.
• W2069311331 cites W1963788090 @default.
• W2069311331 cites W1965305290 @default.
• W2069311331 cites W1966956599 @default.
• W2069311331 cites W1970339131 @default.
• W2069311331 cites W1970617579 @default.
• W2069311331 cites W1977725794 @default.
• W2069311331 cites W1981379485 @default.
• W2069311331 cites W1984554847 @default.
• W2069311331 cites W1990650378 @default.
• W2069311331 cites W2007034511 @default.
• W2069311331 cites W2011326452 @default.
• W2069311331 cites W2014104667 @default.
• W2069311331 cites W2015126555 @default.
• W2069311331 cites W2017791457 @default.
• W2069311331 cites W2024993320 @default.
• W2069311331 cites W2034137241 @default.
• W2069311331 cites W2040995746 @default.
• W2069311331 cites W2054797412 @default.
• W2069311331 cites W2061464631 @default.
• W2069311331 cites W2064367025 @default.
• W2069311331 cites W2066301717 @default.
• W2069311331 cites W2069657766 @default.
• W2069311331 cites W2075460226 @default.
• W2069311331 cites W2098927213 @default.
• W2069311331 cites W2103828363 @default.
• W2069311331 cites W2104156656 @default.
• W2069311331 cites W2110722854 @default.
• W2069311331 cites W2117329255 @default.
• W2069311331 cites W2119770208 @default.
• W2069311331 cites W2120336502 @default.
• W2069311331 cites W2123418665 @default.
• W2069311331 cites W2134711325 @default.
• W2069311331 cites W2137059744 @default.
• W2069311331 cites W2140599912 @default.
• W2069311331 cites W2142826449 @default.
• W2069311331 cites W2161121393 @default.
• W2069311331 cites W2161428910 @default.
• W2069311331 cites W2163755116 @default.
• W2069311331 cites W2171491435 @default.
• W2069311331 cites W2267331327 @default.
• W2069311331 doi "https://doi.org/10.1371/journal.pone.0027048" @default.
• W2069311331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3236753" @default.
• W2069311331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22180776" @default.
• W2069311331 hasPublicationYear "2011" @default.
• W2069311331 type Work @default.
• W2069311331 sameAs 2069311331 @default.
• W2069311331 citedByCount "66" @default.
• W2069311331 countsByYear W20693113312012 @default.
• W2069311331 countsByYear W20693113312013 @default.
• W2069311331 countsByYear W20693113312014 @default.
• W2069311331 countsByYear W20693113312015 @default.
• W2069311331 countsByYear W20693113312016 @default.
• W2069311331 countsByYear W20693113312017 @default.
• W2069311331 countsByYear W20693113312018 @default.
• W2069311331 countsByYear W20693113312019 @default.
• W2069311331 countsByYear W20693113312020 @default.
• W2069311331 countsByYear W20693113312021 @default.
• W2069311331 countsByYear W20693113312022 @default.
• W2069311331 countsByYear W20693113312023 @default.
• W2069311331 crossrefType "journal-article" @default.
• W2069311331 hasAuthorship W2069311331A5012076614 @default.
• W2069311331 hasAuthorship W2069311331A5014321400 @default.
• W2069311331 hasAuthorship W2069311331A5016272404 @default.
• W2069311331 hasAuthorship W2069311331A5026068118 @default.
• W2069311331 hasAuthorship W2069311331A5026469672 @default.
• W2069311331 hasAuthorship W2069311331A5042956844 @default.
• W2069311331 hasAuthorship W2069311331A5048547119 @default.
• W2069311331 hasAuthorship W2069311331A5055208450 @default.
• W2069311331 hasAuthorship W2069311331A5081934281 @default.
• W2069311331 hasBestOaLocation W20693113311 @default.
• W2069311331 hasConcept C168258287 @default.
• W2069311331 hasConcept C169760540 @default.
• W2069311331 hasConcept C170493617 @default.
• W2069311331 hasConcept C17077164 @default.
• W2069311331 hasConcept C2777771985 @default.
• W2069311331 hasConcept C2779046065 @default.
• W2069311331 hasConcept C2779177108 @default.
• W2069311331 hasConcept C2779296341 @default.
• W2069311331 hasConcept C55493867 @default.
• W2069311331 hasConcept C58207958 @default.

• next