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- W2069317205 abstract "Recent studies indicate that abnormalities of the interleukin-3 receptor (IL-3R) are frequently observed in acute myeloid leukemias (AMLs) and may contribute to the proliferative advantage of leukemic blasts. This review analyzes the evidences indicating that the IL-3R represents one of the target molecules involved in the stimulation of proliferation of AMLs, and the overexpression of the IL-3Rα chain may represent one of the mechanisms contributing to the development of a highly malignant leukemic phenotype. Furthermore, there is evidence that the IL-3Rα is a marker of leukemic stem cells, at variance with normal stem cells that are IL-3Rα−. Finally, the IL-3R may represent an important target for the development of new antileukemic drugs." @default.
- W2069317205 created "2016-06-24" @default.
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- W2069317205 creator A5077955076 @default.
- W2069317205 creator A5080705162 @default.
- W2069317205 date "2003-12-04" @default.
- W2069317205 modified "2023-10-17" @default.
- W2069317205 title "Interleukin-3 receptor in acute leukemia" @default.
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- W2069317205 doi "https://doi.org/10.1038/sj.leu.2403224" @default.
- W2069317205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14671644" @default.
- W2069317205 hasPublicationYear "2003" @default.
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