FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069336384> ?p ?o ?g. }

• W2069336384 endingPage "66" @default.
• W2069336384 startingPage "52" @default.
• W2069336384 abstract "Abstract Background : The current dogma of establishing intra-laboratory reference limits (RLs) and their periodical reviewing cannot be fulfilled by most laboratories due to the expenses involved. Thus, most laboratories adopt RLs from external sources often neglecting the problems of transferability. Presently accepted validation concepts still require experimental expenses. Several attempts were undertaken to derive RLs from the large data pools stored in modern laboratory information systems. Former indirect procedures were not generally accepted, but were recently further developed and combined with direct exclusion criteria and applied to estimate RLs of the catalytic activity concentrations of enzymes. This approach was now applied to several electrolytes in serum and plasma most commonly applied in clinical chemistry. Methods : A smoothed kernel density function was estimated for the distribution of the mixed data of the sample group (combined data of non-diseased and diseased subjects). It was assumed that the “central” part of the distribution of all data represents the non-diseased (“healthy”) population (non-pathological values) with high probability. The central part was defined by truncation points using an optimisation method, and was used to estimate a Gaussian distribution of the values of non-diseased subjects. This distribution was now considered as the distribution of the non-diseased subgroup. The percentiles of this parametrical distribution were calculated to obtain unimodal reference intervals. Results : The RLs obtained from different laboratories were similar to recently published values established by direct procedures. Stratification for gender was not necessary, but in some cases for age. With rising age, an increase of the upper RL and of the reference range was observed for potassium. Hospitalisation affected the RLs of sodium, potassium, calcium and magnesium, but not of phosphate. In the case of sodium, the data of at least five regional laboratories could be combined to common RLs. The presented indirect procedure was further validated with a large dataset of potassium concentrations from the NHANES III study with five groups of different health status. Conclusions : The proposed strategy of combining exclusion criteria with an indirect method led to RLs from intra-laboratory data pools for electrolytes which were plausible in comparison to published data obtained by the generally accepted direct approach. The combined concept, however, still requires further investigations. Therefore, it is presently only recommended for checking and reviewing already existing RLs." @default.
• W2069336384 created "2016-06-24" @default.
• W2069336384 creator A5006550341 @default.
• W2069336384 creator A5011684907 @default.
• W2069336384 creator A5029221416 @default.
• W2069336384 creator A5029651572 @default.
• W2069336384 creator A5036049587 @default.
• W2069336384 creator A5039532224 @default.
• W2069336384 creator A5043884873 @default.
• W2069336384 creator A5058935017 @default.
• W2069336384 creator A5074297688 @default.
• W2069336384 creator A5085524727 @default.
• W2069336384 creator A5089136402 @default.
• W2069336384 date "2009-03-01" @default.
• W2069336384 modified "2023-09-27" @default.
• W2069336384 title "An improved indirect approach for determining reference limits from intra-laboratory data bases exemplified by concentrations of electrolytes / Ein verbesserter indirekter Ansatz zur Bestimmung von Referenzgrenzen mittels intra-laboratorieller Datensätze am Beispiel von Elektrolyt-Konzentrationen" @default.
• W2069336384 cites W1507985183 @default.
• W2069336384 cites W1855918737 @default.
• W2069336384 cites W1873859372 @default.
• W2069336384 cites W1934780675 @default.
• W2069336384 cites W1935786512 @default.
• W2069336384 cites W1947856078 @default.
• W2069336384 cites W1958150451 @default.
• W2069336384 cites W1960418068 @default.
• W2069336384 cites W1963862177 @default.
• W2069336384 cites W1964623652 @default.
• W2069336384 cites W1970399746 @default.
• W2069336384 cites W1973207347 @default.
• W2069336384 cites W1981856041 @default.
• W2069336384 cites W1983265149 @default.
• W2069336384 cites W2013373048 @default.
• W2069336384 cites W2019688078 @default.
• W2069336384 cites W2033567952 @default.
• W2069336384 cites W2036307559 @default.
• W2069336384 cites W2041288922 @default.
• W2069336384 cites W2043055225 @default.
• W2069336384 cites W2052498077 @default.
• W2069336384 cites W2068080867 @default.
• W2069336384 cites W2076172320 @default.
• W2069336384 cites W2078494459 @default.
• W2069336384 cites W2100792123 @default.
• W2069336384 cites W2109430357 @default.
• W2069336384 cites W2124186730 @default.
• W2069336384 cites W2127311450 @default.
• W2069336384 cites W2137249683 @default.
• W2069336384 cites W2142476666 @default.
• W2069336384 cites W2145722802 @default.
• W2069336384 cites W2171503863 @default.
• W2069336384 cites W2232642378 @default.
• W2069336384 cites W2321672962 @default.
• W2069336384 cites W2328838466 @default.
• W2069336384 cites W2415990698 @default.
• W2069336384 doi "https://doi.org/10.1515/jlm.2009.015" @default.
• W2069336384 hasPublicationYear "2009" @default.
• W2069336384 type Work @default.
• W2069336384 sameAs 2069336384 @default.
• W2069336384 citedByCount "29" @default.
• W2069336384 countsByYear W20693363842012 @default.
• W2069336384 countsByYear W20693363842013 @default.
• W2069336384 countsByYear W20693363842015 @default.
• W2069336384 countsByYear W20693363842019 @default.
• W2069336384 countsByYear W20693363842020 @default.
• W2069336384 countsByYear W20693363842021 @default.
• W2069336384 countsByYear W20693363842022 @default.
• W2069336384 countsByYear W20693363842023 @default.
• W2069336384 crossrefType "journal-article" @default.
• W2069336384 hasAuthorship W2069336384A5006550341 @default.
• W2069336384 hasAuthorship W2069336384A5011684907 @default.
• W2069336384 hasAuthorship W2069336384A5029221416 @default.
• W2069336384 hasAuthorship W2069336384A5029651572 @default.
• W2069336384 hasAuthorship W2069336384A5036049587 @default.
• W2069336384 hasAuthorship W2069336384A5039532224 @default.
• W2069336384 hasAuthorship W2069336384A5043884873 @default.
• W2069336384 hasAuthorship W2069336384A5058935017 @default.
• W2069336384 hasAuthorship W2069336384A5074297688 @default.
• W2069336384 hasAuthorship W2069336384A5085524727 @default.
• W2069336384 hasAuthorship W2069336384A5089136402 @default.
• W2069336384 hasBestOaLocation W20693363841 @default.
• W2069336384 hasConcept C105795698 @default.
• W2069336384 hasConcept C122048520 @default.
• W2069336384 hasConcept C126322002 @default.
• W2069336384 hasConcept C140331021 @default.
• W2069336384 hasConcept C147597530 @default.
• W2069336384 hasConcept C149782125 @default.
• W2069336384 hasConcept C163716315 @default.
• W2069336384 hasConcept C185592680 @default.
• W2069336384 hasConcept C198531522 @default.
• W2069336384 hasConcept C28826006 @default.
• W2069336384 hasConcept C2908647359 @default.
• W2069336384 hasConcept C2985213535 @default.
• W2069336384 hasConcept C33923547 @default.
• W2069336384 hasConcept C41008148 @default.
• W2069336384 hasConcept C43617362 @default.
• W2069336384 hasConcept C61272859 @default.
• W2069336384 hasConcept C71924100 @default.
• W2069336384 hasConcept C99454951 @default.
• W2069336384 hasConceptScore W2069336384C105795698 @default.
• W2069336384 hasConceptScore W2069336384C122048520 @default.

• next