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- W2069343213 endingPage "738" @default.
- W2069343213 startingPage "723" @default.
- W2069343213 abstract "Cocaine addiction is a major health problem that affects millions of people. Cocaine acts by inhibiting dopamine, noradrenaline and serotonin [5-hydroxytryptamine(5-HT)] reuptake. The dopaminergic system is generally assumed to be involved in the reinforcing aspects of the drug, but the role of 5-HT in the addictive potential of cocaine is unclear. In light of pharmacological manipulations and cocaine use-related disease states affecting brain 5-HT levels, we review studies on the effect of cocaine on central 5-HT function. In addition, the contribution of 5-HT to the rewarding, aversive, discriminative and subjective, as well as the motivational and reinforcing effects of cocaine is discussed. We specifically focus on net changes in the extracellular 5-HT levels that occur as a consequence of acute and chronic cocaine exposure and how these influence cocaine abuse-related behaviour. Overall, the data indicate that 5-HT plays a major role in the psychomotor stimulant, rewarding and discriminative stimulant effects of cocaine, but also affects the motivational and reinforcing effects of the drug. In addition, 5-HT mediates, to some extent, the aversive effects of cocaine. Difficulties with data interpretation are discussed." @default.
- W2069343213 created "2016-06-24" @default.
- W2069343213 creator A5048411779 @default.
- W2069343213 creator A5051435669 @default.
- W2069343213 creator A5072107327 @default.
- W2069343213 creator A5090899863 @default.
- W2069343213 date "2011-12-01" @default.
- W2069343213 modified "2023-10-12" @default.
- W2069343213 title "The interplay between brain 5-hydroxytryptamine levels and cocaine addiction" @default.
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