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- W2069374962 abstract "Abstract We report here comparative studies performed in mice on the toxic and therapeutic effects of free and DNA bound anthracyclines: daunorubicin (DNR) and adriamycin or doxorubicin (ADR). DNR-DNA is less toxic than DNR when given i.p., while a similar overall toxicity is observed when the drugs are given i.v. In contrast, ADR-DNA is significantly less toxic than ADR, both by the i.p. or the i.v. route. The better therapeutic effectiveness of DNR-DNA on L 1210 leukemia compared with free DNR is demonstrated; however, the activities of both DNR and DNR-DNA are dependent on the schedule of administration. The most striking chemotherapic effect is always obtained with ADR-DNA, due to the combination of a higher activity and a lower toxicity when the drug is associated to high mol. wt DNA. The results of the toxicologic and chemotherapic studies are discussed in view of the distinctive pharmacologic properties of free and DNA bound drugs." @default.
- W2069374962 created "2016-06-24" @default.
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- W2069374962 date "1980-08-01" @default.
- W2069374962 modified "2023-09-26" @default.
- W2069374962 title "DNA—Anthracycline complexes. I. Toxicity in mice and chemotherapeutic activity against L1210 leukemia of daunorubicin—DNA and adriamycin—DNA" @default.
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- W2069374962 doi "https://doi.org/10.1016/0014-2964(80)90243-1" @default.
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