FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069382664> ?p ?o ?g. }

• W2069382664 abstract "Long-term potentiation (LTP) is a key element of synaptic plasticity. At the macroscopic level, similar effects can be induced in the human brain using repetitive stimulation with identical stimuli. High-frequency stimulation (HFS) can increase neuronal responses whereas low-frequency stimulation may produce the opposite effect. Optimal stimulation frequencies and characteristics for inducing stimulus-specific response modification (SRM) differ substantially from those applied to brain tissue slices but have been explored in recent studies. In contrast, the individual manifestation of this effect in terms of its spatial location and extent are unclear. Using functional magnetic resonance imaging (fMRI) in 18 subjects (mean age 25.3 years), we attempted to induce LTP-like effects by HFS with checkerboard flashes at 9 Hz for 120 s. As expected, flashes induced strong activation in primary and secondary visual cortices. Contrary to our expectations, we found clusters of decreased activations induced by pattern flashes after HFS in the primary and secondary visual cortices. On the level of the individual subject, some showed significantly increased activations in the post-HFS session while the majority showed significant decreases. The locations of areas showing altered activations before and after HFS were only partly overlapping. No association between location, extent and direction of the HFS-effect was observed. The findings are unexpected in the light of existing HFS-studies, but mirror the high inter-subject variability, concerning even the directionality of the induced effects shown for other indices of LTP-like plasticity in the human brain. As this variability is not observed in LTP at the cellular level, a better understanding of LTP-like mechanisms on the macroscopic level is essential for establishing tools to quantify individual synaptic plasticity in-vivo." @default.
• W2069382664 created "2016-06-24" @default.
• W2069382664 creator A5006147350 @default.
• W2069382664 creator A5007738782 @default.
• W2069382664 creator A5018278195 @default.
• W2069382664 creator A5023518719 @default.
• W2069382664 creator A5047882486 @default.
• W2069382664 creator A5059709728 @default.
• W2069382664 creator A5076944138 @default.
• W2069382664 creator A5078091560 @default.
• W2069382664 date "2014-09-08" @default.
• W2069382664 modified "2023-09-23" @default.
• W2069382664 title "Heterogeneity of stimulus-specific response modification—an fMRI study on neuroplasticity" @default.
• W2069382664 cites W1693245692 @default.
• W2069382664 cites W1963633820 @default.
• W2069382664 cites W1977022762 @default.
• W2069382664 cites W1983834279 @default.
• W2069382664 cites W1984725792 @default.
• W2069382664 cites W1984853516 @default.
• W2069382664 cites W1990232177 @default.
• W2069382664 cites W1991873473 @default.
• W2069382664 cites W1991952911 @default.
• W2069382664 cites W1992156655 @default.
• W2069382664 cites W1995004052 @default.
• W2069382664 cites W1995698894 @default.
• W2069382664 cites W1997882637 @default.
• W2069382664 cites W2009782005 @default.
• W2069382664 cites W2016722541 @default.
• W2069382664 cites W2017145381 @default.
• W2069382664 cites W2020046883 @default.
• W2069382664 cites W2022047741 @default.
• W2069382664 cites W2028249370 @default.
• W2069382664 cites W2028360261 @default.
• W2069382664 cites W2032210947 @default.
• W2069382664 cites W2044032804 @default.
• W2069382664 cites W2052404970 @default.
• W2069382664 cites W2056678372 @default.
• W2069382664 cites W2060419273 @default.
• W2069382664 cites W2065585647 @default.
• W2069382664 cites W2098146251 @default.
• W2069382664 cites W2098708988 @default.
• W2069382664 cites W2101562854 @default.
• W2069382664 cites W2101963369 @default.
• W2069382664 cites W2112056381 @default.
• W2069382664 cites W2113820953 @default.
• W2069382664 cites W2122778405 @default.
• W2069382664 cites W2133031929 @default.
• W2069382664 cites W2133276620 @default.
• W2069382664 cites W2134927362 @default.
• W2069382664 cites W2147101007 @default.
• W2069382664 cites W2152811887 @default.
• W2069382664 cites W4230920194 @default.
• W2069382664 cites W2185212694 @default.
• W2069382664 doi "https://doi.org/10.3389/fnhum.2014.00695" @default.
• W2069382664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157554" @default.
• W2069382664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25249962" @default.
• W2069382664 hasPublicationYear "2014" @default.
• W2069382664 type Work @default.
• W2069382664 sameAs 2069382664 @default.
• W2069382664 citedByCount "14" @default.
• W2069382664 countsByYear W20693826642015 @default.
• W2069382664 countsByYear W20693826642016 @default.
• W2069382664 countsByYear W20693826642017 @default.
• W2069382664 countsByYear W20693826642018 @default.
• W2069382664 countsByYear W20693826642019 @default.
• W2069382664 countsByYear W20693826642020 @default.
• W2069382664 countsByYear W20693826642021 @default.
• W2069382664 countsByYear W20693826642022 @default.
• W2069382664 crossrefType "journal-article" @default.
• W2069382664 hasAuthorship W2069382664A5006147350 @default.
• W2069382664 hasAuthorship W2069382664A5007738782 @default.
• W2069382664 hasAuthorship W2069382664A5018278195 @default.
• W2069382664 hasAuthorship W2069382664A5023518719 @default.
• W2069382664 hasAuthorship W2069382664A5047882486 @default.
• W2069382664 hasAuthorship W2069382664A5059709728 @default.
• W2069382664 hasAuthorship W2069382664A5076944138 @default.
• W2069382664 hasAuthorship W2069382664A5078091560 @default.
• W2069382664 hasBestOaLocation W20693826641 @default.
• W2069382664 hasConcept C126322002 @default.
• W2069382664 hasConcept C15744967 @default.
• W2069382664 hasConcept C169760540 @default.
• W2069382664 hasConcept C170493617 @default.
• W2069382664 hasConcept C178253425 @default.
• W2069382664 hasConcept C180747234 @default.
• W2069382664 hasConcept C24998067 @default.
• W2069382664 hasConcept C25274449 @default.
• W2069382664 hasConcept C26760741 @default.
• W2069382664 hasConcept C2777670902 @default.
• W2069382664 hasConcept C2778581513 @default.
• W2069382664 hasConcept C2779226451 @default.
• W2069382664 hasConcept C2779345533 @default.
• W2069382664 hasConcept C2779918689 @default.
• W2069382664 hasConcept C2908832724 @default.
• W2069382664 hasConcept C29648211 @default.
• W2069382664 hasConcept C2985799443 @default.
• W2069382664 hasConcept C47611674 @default.
• W2069382664 hasConcept C54355233 @default.
• W2069382664 hasConcept C71924100 @default.
• W2069382664 hasConcept C86803240 @default.
• W2069382664 hasConcept C98229152 @default.

• next