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• W2069405087 abstract "Background: Several findings suggest that nitric oxide (NO) plays a significant role in the regulation of the Th1/Th2 balance and contributes to the development of allergic diseases. Our study investigates a possible association of C/T transition located 276‐bp downstream from the translation termination site in exon 29 of the human nitric oxide synthase type 1 ( NOS1 ) gene with immunoglobulin E (IgE)‐mediated allergic diseases in the Czech population. Methods: The study included 688 subjects – 368 patients with clinically manifested allergic diseases and 320 unrelated controls with negative familial history of asthma/atopy. The NOS1 genotypes were determined by polymerase chain reaction (PCR) and restriction analysis by Eco 72I. Results: No significant differences were found for allele or genotype frequencies of the 5266 C/T polymorphism in exon 29 of the NOS1 gene between IgE‐mediated allergic diseases (or asthma alone) and healthy subjects. However, this common polymorphism showed a significant association with signs of atopy, especially with total serum IgE levels [log e IgE levels (mean ± SD): CC genotype = 4.34 ± 1.40; CT genotype = 4.58 ± 1.53; TT genotype = 5.01 ± 1.61; P < 0.05). Conclusions: Our findings suggest that NOS1 gene may participate in the pathogenesis of high total serum IgE levels in allergic diseases in our population. These findings provide support for NOS1 as a candidate gene for IgE‐mediated allergy." @default.
• W2069405087 created "2016-06-24" @default.
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• W2069405087 date "2004-04-06" @default.
• W2069405087 modified "2023-10-15" @default.
• W2069405087 title "Neuronal nitric oxide synthase gene polymorphism and IgE-mediated allergy in the Central European population" @default.
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• W2069405087 doi "https://doi.org/10.1111/j.1398-9995.2004.00458.x" @default.
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