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- W2069414821 abstract "Abstract Two positron‐emitting analogues of tyrosine, O ‐[ 11 C]methyl‐ L ‐tyrosine and O ‐[ 18 F]fluoromethyl‐ L ‐tyrosine were prepared as new tumor imaging agents. The alkylating agent, [ 11 C]methyl triflate or [ 18 F]fluoromethyl triflate, was simply bubbled through a dimethylsulfoxide solution of L ‐tyrosine disodium salt at room temperature. After subsequent HPLC purification the labeled L ‐tyrosine analogues were obtained in decay‐corrected radiochemical yields of over 50%, based on their corresponding labeling agent, with radiochemical purities always higher than 98%. The quite straightforward preparation, together with the high radiochemical yields achieved, make both these syntheses suitable for routine production. Copyright © 2003 John Wiley & Sons, Ltd." @default.
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- W2069414821 date "2003-03-31" @default.
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- W2069414821 title "Radiosynthesis ofO-[11C]methyl-L-tyrosine andO-[18F]Fluoromethyl-L-tyrosine as potential PET tracers for imaging amino acid transport" @default.
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- W2069414821 doi "https://doi.org/10.1002/jlcr.696" @default.
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