Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069416620> ?p ?o ?g. }
- W2069416620 endingPage "758" @default.
- W2069416620 startingPage "754" @default.
- W2069416620 abstract "The purpose of this paper is to suggest a partial explanation of the aetiology of autosomal dominant polycystic kidney disease type 1, one of the most common genetic diseases in humans. To this aim we put forward a number of interconnected ideas, based on a number of experimental evidences and plausibility arguments. We stress the major role played by the instability of some genomic tandem repeats, together with the DNA structures known as quadruplexes, the pseudogenes and the gene conversion. The model we propose can be considered a multi-hit generalization of the well-known two-hit model, a generalization that could well have a validity also outside the specific context. We finally provide an indication of the likely guilty DNA segment for the above disease, and we propose a possible simple experimental line of action aimed to confirm or disproof our suggestion." @default.
- W2069416620 created "2016-06-24" @default.
- W2069416620 creator A5012007149 @default.
- W2069416620 creator A5052752195 @default.
- W2069416620 creator A5060475051 @default.
- W2069416620 creator A5073666123 @default.
- W2069416620 date "2001-12-01" @default.
- W2069416620 modified "2023-09-24" @default.
- W2069416620 title "On new hypotheses about autosomal dominant polycystic kidney disease type 1" @default.
- W2069416620 cites W129160841 @default.
- W2069416620 cites W1551136355 @default.
- W2069416620 cites W1560231616 @default.
- W2069416620 cites W1572071568 @default.
- W2069416620 cites W1578497208 @default.
- W2069416620 cites W1908011278 @default.
- W2069416620 cites W1970086776 @default.
- W2069416620 cites W1977300744 @default.
- W2069416620 cites W1977660940 @default.
- W2069416620 cites W1984455707 @default.
- W2069416620 cites W1992960888 @default.
- W2069416620 cites W2005026678 @default.
- W2069416620 cites W2005534453 @default.
- W2069416620 cites W2022012638 @default.
- W2069416620 cites W2031328533 @default.
- W2069416620 cites W2038909539 @default.
- W2069416620 cites W2039214189 @default.
- W2069416620 cites W2041245661 @default.
- W2069416620 cites W2049151807 @default.
- W2069416620 cites W2068160148 @default.
- W2069416620 cites W2069003894 @default.
- W2069416620 cites W2071302452 @default.
- W2069416620 cites W2076433744 @default.
- W2069416620 cites W2077858999 @default.
- W2069416620 cites W2088237310 @default.
- W2069416620 cites W2088811685 @default.
- W2069416620 cites W2109234462 @default.
- W2069416620 cites W2121359743 @default.
- W2069416620 cites W2124750046 @default.
- W2069416620 cites W2125780462 @default.
- W2069416620 cites W2133532840 @default.
- W2069416620 cites W2162112306 @default.
- W2069416620 cites W2166448583 @default.
- W2069416620 cites W2167527247 @default.
- W2069416620 cites W2170826153 @default.
- W2069416620 cites W2223063733 @default.
- W2069416620 cites W2319095608 @default.
- W2069416620 doi "https://doi.org/10.1054/mehy.2001.1482" @default.
- W2069416620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11918441" @default.
- W2069416620 hasPublicationYear "2001" @default.
- W2069416620 type Work @default.
- W2069416620 sameAs 2069416620 @default.
- W2069416620 citedByCount "2" @default.
- W2069416620 crossrefType "journal-article" @default.
- W2069416620 hasAuthorship W2069416620A5012007149 @default.
- W2069416620 hasAuthorship W2069416620A5052752195 @default.
- W2069416620 hasAuthorship W2069416620A5060475051 @default.
- W2069416620 hasAuthorship W2069416620A5073666123 @default.
- W2069416620 hasConcept C104317684 @default.
- W2069416620 hasConcept C111472728 @default.
- W2069416620 hasConcept C138885662 @default.
- W2069416620 hasConcept C141231307 @default.
- W2069416620 hasConcept C142724271 @default.
- W2069416620 hasConcept C151730666 @default.
- W2069416620 hasConcept C177148314 @default.
- W2069416620 hasConcept C2776266639 @default.
- W2069416620 hasConcept C2779134260 @default.
- W2069416620 hasConcept C2779343474 @default.
- W2069416620 hasConcept C2780091579 @default.
- W2069416620 hasConcept C34957205 @default.
- W2069416620 hasConcept C54355233 @default.
- W2069416620 hasConcept C70721500 @default.
- W2069416620 hasConcept C71924100 @default.
- W2069416620 hasConcept C86803240 @default.
- W2069416620 hasConceptScore W2069416620C104317684 @default.
- W2069416620 hasConceptScore W2069416620C111472728 @default.
- W2069416620 hasConceptScore W2069416620C138885662 @default.
- W2069416620 hasConceptScore W2069416620C141231307 @default.
- W2069416620 hasConceptScore W2069416620C142724271 @default.
- W2069416620 hasConceptScore W2069416620C151730666 @default.
- W2069416620 hasConceptScore W2069416620C177148314 @default.
- W2069416620 hasConceptScore W2069416620C2776266639 @default.
- W2069416620 hasConceptScore W2069416620C2779134260 @default.
- W2069416620 hasConceptScore W2069416620C2779343474 @default.
- W2069416620 hasConceptScore W2069416620C2780091579 @default.
- W2069416620 hasConceptScore W2069416620C34957205 @default.
- W2069416620 hasConceptScore W2069416620C54355233 @default.
- W2069416620 hasConceptScore W2069416620C70721500 @default.
- W2069416620 hasConceptScore W2069416620C71924100 @default.
- W2069416620 hasConceptScore W2069416620C86803240 @default.
- W2069416620 hasIssue "6" @default.
- W2069416620 hasLocation W20694166201 @default.
- W2069416620 hasLocation W20694166202 @default.
- W2069416620 hasOpenAccess W2069416620 @default.
- W2069416620 hasPrimaryLocation W20694166201 @default.
- W2069416620 hasRelatedWork W1565897669 @default.
- W2069416620 hasRelatedWork W2007559212 @default.
- W2069416620 hasRelatedWork W2014831367 @default.
- W2069416620 hasRelatedWork W2018135334 @default.