FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069417375> ?p ?o ?g. }

• W2069417375 endingPage "e57820" @default.
• W2069417375 startingPage "e57820" @default.
• W2069417375 abstract "Pathology studies of progressive multiple sclerosis (MS) indicate a major role of inflammation including Th17-cells and meningeal inflammation with ectopic lymphoid follicles, B-cells and plasma cells, the latter indicating a possible role of the newly identified subset of follicular T-helper (TFH) cells. Although previous studies reported increased systemic inflammation in progressive MS it remains unclear whether systemic inflammation contributes to disease progression and intrathecal inflammation. This study aimed to investigate systemic inflammation in progressive MS and its relationship with disease progression, using flow cytometry and gene expression analysis of CD4+ and CD8+T-cells, B-cells, monocytes and dendritic cells. Furthermore, gene expression of cerebrospinal fluid cells was studied. Flow cytometry studies revealed increased frequencies of ICOS+TFH-cells in peripheral blood from relapsing-remitting (RRMS) and secondary progressive (SPMS) MS patients. All MS subtypes had decreased frequencies of Th1 TFH-cells, while primary progressive (PPMS) MS patients had increased frequency of Th17 TFH-cells. The Th17-subset, interleukin-23-receptor+CD4+T-cells, was significantly increased in PPMS and SPMS. In the analysis of B-cells, we found a significant increase of plasmablasts and DC-SIGN+ and CD83+B-cells in SPMS. ICOS+TFH-cells and DC-SIGN+B-cells correlated with disease progression in SPMS patients. Gene expression analysis of peripheral blood cell subsets substantiated the flow cytometry findings by demonstrating increased expression of IL21, IL21R and ICOS in CD4+T-cells in progressive MS. Cerebrospinal fluid cells from RRMS and progressive MS (pooled SPMS and PPMS patients) had increased expression of TFH-cell and plasmablast markers. In conclusion, this study is the first to demonstrate the potential involvement of activated TFH-cells in MS. The increased frequencies of Th17-cells, activated TFH- and B-cells parallel findings from pathology studies which, along with the correlation between activated TFH- and B-cells and disease progression, suggest a pathogenic role of systemic inflammation in progressive MS. These observations may have implications for the treatment of progressive MS." @default.
• W2069417375 created "2016-06-24" @default.
• W2069417375 creator A5003414068 @default.
• W2069417375 creator A5015275115 @default.
• W2069417375 creator A5032352236 @default.
• W2069417375 creator A5038376395 @default.
• W2069417375 creator A5066796645 @default.
• W2069417375 creator A5069293732 @default.
• W2069417375 creator A5080540005 @default.
• W2069417375 creator A5081657251 @default.
• W2069417375 date "2013-03-01" @default.
• W2069417375 modified "2023-10-06" @default.
• W2069417375 title "Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression" @default.
• W2069417375 cites W1937650001 @default.
• W2069417375 cites W1964895626 @default.
• W2069417375 cites W1965842742 @default.
• W2069417375 cites W1968545392 @default.
• W2069417375 cites W1971340033 @default.
• W2069417375 cites W1977581686 @default.
• W2069417375 cites W1981621288 @default.
• W2069417375 cites W1983093750 @default.
• W2069417375 cites W1991842536 @default.
• W2069417375 cites W1994995252 @default.
• W2069417375 cites W1995460125 @default.
• W2069417375 cites W1996918660 @default.
• W2069417375 cites W1997275623 @default.
• W2069417375 cites W1998168378 @default.
• W2069417375 cites W2000049562 @default.
• W2069417375 cites W2004720857 @default.
• W2069417375 cites W2006522040 @default.
• W2069417375 cites W2007547035 @default.
• W2069417375 cites W2009995539 @default.
• W2069417375 cites W2013481339 @default.
• W2069417375 cites W2015378442 @default.
• W2069417375 cites W2016844693 @default.
• W2069417375 cites W2019926860 @default.
• W2069417375 cites W2021633591 @default.
• W2069417375 cites W2026218766 @default.
• W2069417375 cites W2041508820 @default.
• W2069417375 cites W2045675660 @default.
• W2069417375 cites W2046188285 @default.
• W2069417375 cites W2046637170 @default.
• W2069417375 cites W2047062145 @default.
• W2069417375 cites W2065669145 @default.
• W2069417375 cites W2074407393 @default.
• W2069417375 cites W2083837388 @default.
• W2069417375 cites W2085161284 @default.
• W2069417375 cites W2086196933 @default.
• W2069417375 cites W2104450494 @default.
• W2069417375 cites W2106980391 @default.
• W2069417375 cites W2107008240 @default.
• W2069417375 cites W2107498883 @default.
• W2069417375 cites W2116686907 @default.
• W2069417375 cites W2118818657 @default.
• W2069417375 cites W2122082443 @default.
• W2069417375 cites W2122542523 @default.
• W2069417375 cites W2129134090 @default.
• W2069417375 cites W2129302556 @default.
• W2069417375 cites W2131288952 @default.
• W2069417375 cites W2134342374 @default.
• W2069417375 cites W2136278403 @default.
• W2069417375 cites W2141111992 @default.
• W2069417375 cites W2151566115 @default.
• W2069417375 cites W2160385287 @default.
• W2069417375 cites W2160872052 @default.
• W2069417375 cites W2160890577 @default.
• W2069417375 cites W2161607126 @default.
• W2069417375 cites W2167010530 @default.
• W2069417375 cites W2326826867 @default.
• W2069417375 cites W4236472486 @default.
• W2069417375 doi "https://doi.org/10.1371/journal.pone.0057820" @default.
• W2069417375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6061580" @default.
• W2069417375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29294474" @default.
• W2069417375 hasPublicationYear "2013" @default.
• W2069417375 type Work @default.
• W2069417375 sameAs 2069417375 @default.
• W2069417375 citedByCount "198" @default.
• W2069417375 countsByYear W20694173752013 @default.
• W2069417375 countsByYear W20694173752014 @default.
• W2069417375 countsByYear W20694173752015 @default.
• W2069417375 countsByYear W20694173752016 @default.
• W2069417375 countsByYear W20694173752017 @default.
• W2069417375 countsByYear W20694173752018 @default.
• W2069417375 countsByYear W20694173752019 @default.
• W2069417375 countsByYear W20694173752020 @default.
• W2069417375 countsByYear W20694173752021 @default.
• W2069417375 countsByYear W20694173752022 @default.
• W2069417375 countsByYear W20694173752023 @default.
• W2069417375 crossrefType "journal-article" @default.
• W2069417375 hasAuthorship W2069417375A5003414068 @default.
• W2069417375 hasAuthorship W2069417375A5015275115 @default.
• W2069417375 hasAuthorship W2069417375A5032352236 @default.
• W2069417375 hasAuthorship W2069417375A5038376395 @default.
• W2069417375 hasAuthorship W2069417375A5066796645 @default.
• W2069417375 hasAuthorship W2069417375A5069293732 @default.
• W2069417375 hasAuthorship W2069417375A5080540005 @default.
• W2069417375 hasAuthorship W2069417375A5081657251 @default.
• W2069417375 hasBestOaLocation W20694173751 @default.

• next