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• W2069422660 abstract "Donor-specific tolerance to heart allograft was induced in adult Lewis rats by pregraft donor-specific blood transfusion (DST). We previously showed that this tolerant state is characterized by a dramatic inhibition of T cell and macrophage activation. In addition, tolerant animals could not mount an efficient anti-donor humoral response whereas transfer of sera from rejecting animals triggered rejection in tolerant animals. This tolerance can be abrogated by daily post-graft administration of recombinant IFN-γ (rIFN-γ). To elucidate the mechanisms of action of rIFN-γ, T cell, macrophage and B cell functions were assessed in allograft recipients. IFN-γ did not restore the expression of Th1-related cytokine mRNA or the activated macrophage product inducible nitric oxide synthase in allografts. Importantly, rIFN-γ treatment promptly restored the anti-donor humoral response in DST-treated recipients. We conclude that rIFN-γ treatment in DST-treated allograft recipients cannot reverse the unresponsive state of Th1 cells and macrophages infiltrating the graft, but can provide B cell help for IgG alloantibody production which is lacking in these animals." @default.
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• W2069422660 date "1999-01-01" @default.
• W2069422660 modified "2023-09-25" @default.
• W2069422660 title "Recombinant IFN-γ abrogates allograft tolerance induced by donor-specific blood transfusion by restoring alloantibody production" @default.
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• W2069422660 doi "https://doi.org/10.1002/(sici)1521-4141(199901)29:01<317::aid-immu317>3.0.co;2-o" @default.
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