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- W2069427212 abstract "Quinidine has been used in the successful treatment of cardiac arrhythmias for over two decades. However, its toxicity, including nausea, vomiting, diarrhea, and more serious problems of arrhythmias and sudden death has limited its usefulness in certain situations. Of particular note is the gastrointestinal intolerance that many patients experience. It is estimated that nausea, vomiting, and diarrhea occur in 30 per cent of patients ingesting quinidine, requiring discontinuation of therapy in as many as 10 per cent’-” These side effects are not related to dose or to blood levels. They are believed to be due to a direct stimulant action on the smooth muscle of the small intestine.’ We have encountered patients who have required quinidine for the successful control of their arrhythmias, but who could not tolerate the resulting gastrointestinal symptoms, particularly diarrhea. Concomitant administration of aluminum hydroxide gel with their quinidine dose resulted in reduction of diarrhea, with apparently continued control of their arrhythmias. Previous reports of interference with drug absorption by antacids prompted a study to determine the effects of aluminum hydroxide gel on quinidine absorption.”" @default.
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- W2069427212 date "1978-10-01" @default.
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- W2069427212 title "The noninterference of aluminum hydroxide gel with quinidine sulfate absorption: An approach to control quinidine-induced diarrhea" @default.
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- W2069427212 doi "https://doi.org/10.1016/0002-8703(78)90164-3" @default.
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