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- W2069437145 abstract "Severe combined immunodeficiency (SCID) mice can be stably grafted with human peripheral blood lymphocytes, creating hu-PBL-SCID chimeras; essentially, these are mice with a human immune system. Here, Magdalena Tary-Lehmann, Andrew Saxon and Paul Lehmann discuss the immunobiology of these chimeras. The authors propose that hu-PBL-SCID chimerism evolves in two phases. During the first three weeks after grafting, many of the injected cells survive and the human immune system is functional. Subsequently, anti-mouse-reactive clones are selected and the immune system becomes nonfunctional. The implications of this scenario for the utilization of the hu-PBL-SCID model are discussed." @default.
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- W2069437145 date "1995-11-01" @default.
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- W2069437145 title "The human immune system in hu-PBL-SCID mice" @default.
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- W2069437145 doi "https://doi.org/10.1016/0167-5699(95)80046-8" @default.
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