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- W2069439149 abstract "Heart failure is a leading cause of death globally and while survival after diagnosis has improved over time, the death rate remains high with ≈50% mortality within 5 years of diagnosis [ 1 Judd S.E. Kissela B.M. Kittner S.J. Lackland D.T. Lichtman J.H. Lisabeth L.D. et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014; 129: e28-e292https://doi.org/10.1161/01.cir.0000441139.02102.80 Crossref PubMed Scopus (4366) Google Scholar , 2 Ambrosy A.P. Fonarow G.C. Butler J. Chioncel O. Greene S.J. Vaduganathan M. et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014; 63: 1123-1133https://doi.org/10.1016/j.jacc.2013.11.053 Abstract Full Text Full Text PDF PubMed Scopus (1218) Google Scholar , 3 Gaziano T.A. Cardiovascular disease in the developing world and its cost-effective management. Circulation. 2005; 112: 3547-3553https://doi.org/10.1161/CIRCULATIONAHA.105.591792 Crossref PubMed Scopus (280) Google Scholar ]. In the USA, the total annual cost of heart failure is estimated to be greater than 30 billion dollars and is expected to more than double over the next decade, due to an aging population [ [4] Heidenreich P.A. Albert N.M. Allen L.A. Bluemke D.A. Butler J. Fonarow G.C. et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013; 6: 606-619https://doi.org/10.1161/HHF.0b013e318291329a Crossref PubMed Scopus (1678) Google Scholar ]. Coronary artery disease and related myocardial infarction is the most common cause of heart failure [ [5] Velagaleti R.S. Vasan R.S. Heart failure in the twenty-first century: is it a coronary artery disease or hypertension problem?. Cardiol Clin. 2007; 25: 487-495https://doi.org/10.1016/j.ccl.2007.08.010 Abstract Full Text Full Text PDF PubMed Scopus (60) Google Scholar ]. Hypertension is the next most common cause and historically accounts for ≈25% of heart failure cases [ [6] Kannel W.B. Cobb J. Left ventricular hypertrophy and mortality—results from the Framingham Study. Cardiology. 1992; 81: 291-298 Crossref PubMed Scopus (119) Google Scholar ]." @default.
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- W2069439149 title "Carvedilol protects the infarcted heart by upregulating miR-133: First evidence that disease state affects β-adrenergic arrestin-biased signaling?" @default.
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