Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069439378> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2069439378 abstract "Invariant Natural killer T (iNKT) cells are a subset of lipid-specific T cells, restricted by the MHC-I class like molecule CD1d. A recent study showed a correlation between the co-localization of lipid-loaded CD1d molecules with lipid rafts on the membrane of antigen presenting cells, and their capacity of eliciting secretion of Th1-cytokines by stimulated iNKT cells [1]. Thus, this study suggested that not only the structure of CD1d bound to an exogenous lipid could influence Cd1d-mediated immunity, but also its partitioning on the membrane. Here, we address the spatiotemporal behaviour of α-Galactosylceramide loaded CD1d complexes on the cell membrane of human myeloid cells using multiple colour high-speed single-particle tracking (100 Hz) combined with an iNKT T Cell Receptor-Qdot conjugate as imaging probe. Furthermore, we complement these studies using STED nanoscopy to obtain nanoscale images of CD1d spatial organization. Our results indicate a direct role of the actin cytoskeleton in actively segregating CD1d nanoclusters on the cell membrane resulting in an inhibition of the activation of iNKT cells [2]. As a whole, our work proposes a new paradigm of biophysical interaction between CD1d presenting cells and NKT cells which deviates significantly from classical MHCI/II complexes and CD8/CD4-T Cells interactions.[1] J. S. Im et al., Immunity, 30, 888, 2009.[2] J. A. Torreno-Pina et al., in preparation." @default.
- W2069439378 created "2016-06-24" @default.
- W2069439378 creator A5000565081 @default.
- W2069439378 creator A5016761007 @default.
- W2069439378 creator A5035447101 @default.
- W2069439378 creator A5052577293 @default.
- W2069439378 creator A5058470820 @default.
- W2069439378 creator A5077645019 @default.
- W2069439378 date "2014-01-01" @default.
- W2069439378 modified "2023-10-17" @default.
- W2069439378 title "The Actin Cytoskeleton Controls the Activation of Invariant Natural Killer T Cells by Fine-Tuning CD1d Nanoscale Aggregation on Antigen Presenting Cells" @default.
- W2069439378 doi "https://doi.org/10.1016/j.bpj.2013.11.1394" @default.
- W2069439378 hasPublicationYear "2014" @default.
- W2069439378 type Work @default.
- W2069439378 sameAs 2069439378 @default.
- W2069439378 citedByCount "0" @default.
- W2069439378 crossrefType "journal-article" @default.
- W2069439378 hasAuthorship W2069439378A5000565081 @default.
- W2069439378 hasAuthorship W2069439378A5016761007 @default.
- W2069439378 hasAuthorship W2069439378A5035447101 @default.
- W2069439378 hasAuthorship W2069439378A5052577293 @default.
- W2069439378 hasAuthorship W2069439378A5058470820 @default.
- W2069439378 hasAuthorship W2069439378A5077645019 @default.
- W2069439378 hasBestOaLocation W20694393781 @default.
- W2069439378 hasConcept C104317684 @default.
- W2069439378 hasConcept C105780059 @default.
- W2069439378 hasConcept C120665830 @default.
- W2069439378 hasConcept C121332964 @default.
- W2069439378 hasConcept C127716648 @default.
- W2069439378 hasConcept C139563560 @default.
- W2069439378 hasConcept C147483822 @default.
- W2069439378 hasConcept C167672396 @default.
- W2069439378 hasConcept C170627219 @default.
- W2069439378 hasConcept C185592680 @default.
- W2069439378 hasConcept C203014093 @default.
- W2069439378 hasConcept C2776090121 @default.
- W2069439378 hasConcept C2778607024 @default.
- W2069439378 hasConcept C2778814158 @default.
- W2069439378 hasConcept C2779919695 @default.
- W2069439378 hasConcept C30282128 @default.
- W2069439378 hasConcept C37386791 @default.
- W2069439378 hasConcept C520434653 @default.
- W2069439378 hasConcept C55493867 @default.
- W2069439378 hasConcept C67662055 @default.
- W2069439378 hasConcept C86803240 @default.
- W2069439378 hasConcept C8891405 @default.
- W2069439378 hasConcept C95444343 @default.
- W2069439378 hasConceptScore W2069439378C104317684 @default.
- W2069439378 hasConceptScore W2069439378C105780059 @default.
- W2069439378 hasConceptScore W2069439378C120665830 @default.
- W2069439378 hasConceptScore W2069439378C121332964 @default.
- W2069439378 hasConceptScore W2069439378C127716648 @default.
- W2069439378 hasConceptScore W2069439378C139563560 @default.
- W2069439378 hasConceptScore W2069439378C147483822 @default.
- W2069439378 hasConceptScore W2069439378C167672396 @default.
- W2069439378 hasConceptScore W2069439378C170627219 @default.
- W2069439378 hasConceptScore W2069439378C185592680 @default.
- W2069439378 hasConceptScore W2069439378C203014093 @default.
- W2069439378 hasConceptScore W2069439378C2776090121 @default.
- W2069439378 hasConceptScore W2069439378C2778607024 @default.
- W2069439378 hasConceptScore W2069439378C2778814158 @default.
- W2069439378 hasConceptScore W2069439378C2779919695 @default.
- W2069439378 hasConceptScore W2069439378C30282128 @default.
- W2069439378 hasConceptScore W2069439378C37386791 @default.
- W2069439378 hasConceptScore W2069439378C520434653 @default.
- W2069439378 hasConceptScore W2069439378C55493867 @default.
- W2069439378 hasConceptScore W2069439378C67662055 @default.
- W2069439378 hasConceptScore W2069439378C86803240 @default.
- W2069439378 hasConceptScore W2069439378C8891405 @default.
- W2069439378 hasConceptScore W2069439378C95444343 @default.
- W2069439378 hasLocation W20694393781 @default.
- W2069439378 hasOpenAccess W2069439378 @default.
- W2069439378 hasPrimaryLocation W20694393781 @default.
- W2069439378 hasRelatedWork W106799847 @default.
- W2069439378 hasRelatedWork W1880148174 @default.
- W2069439378 hasRelatedWork W1946086290 @default.
- W2069439378 hasRelatedWork W2015528870 @default.
- W2069439378 hasRelatedWork W2025229322 @default.
- W2069439378 hasRelatedWork W2034544979 @default.
- W2069439378 hasRelatedWork W2057290487 @default.
- W2069439378 hasRelatedWork W2060165194 @default.
- W2069439378 hasRelatedWork W2063026834 @default.
- W2069439378 hasRelatedWork W2077385999 @default.
- W2069439378 hasRelatedWork W2088072253 @default.
- W2069439378 hasRelatedWork W2104105338 @default.
- W2069439378 hasRelatedWork W2122202268 @default.
- W2069439378 hasRelatedWork W2141826840 @default.
- W2069439378 hasRelatedWork W2154620870 @default.
- W2069439378 hasRelatedWork W2268921967 @default.
- W2069439378 hasRelatedWork W2409717020 @default.
- W2069439378 hasRelatedWork W2890882534 @default.
- W2069439378 hasRelatedWork W2960575266 @default.
- W2069439378 hasRelatedWork W32929286 @default.
- W2069439378 isParatext "false" @default.
- W2069439378 isRetracted "false" @default.
- W2069439378 magId "2069439378" @default.
- W2069439378 workType "article" @default.