FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069442595> ?p ?o ?g. }

• W2069442595 endingPage "2484" @default.
• W2069442595 startingPage "2469" @default.
• W2069442595 abstract "Purpose In recent years, the treatment of central giant cell granuloma (CGCG) has become focused on the inhibition of osteoclast differentiation and proliferation. Medications that were developed for the treatment of giant cell tumor of bone and bone resorption from metastatic skeletal disease have shown some success in the treatment of CGCG. The present report describes 2 cases of CGCG of the mandible that were treated effectively with subcutaneous denosumab. Materials and Methods Two cases of histologically diagnosed CGCG of the mandible were treated with monthly subcutaneous injections of denosumab 120 mg primarily or after intralesional corticosteroid therapy. Clinical and radiographic follow-ups were recorded over a period of 24 months (case 1) and 15 months (case 2). Results In the 2 cases, progressive radiodensity and osseous regeneration were noted 4 to 6 months after denosumab therapy was initiated. A decrease in lesion size and improvement in bone contour and facial symmetry were seen in the 2 cases. Conclusion The major radiographic, clinical, and histologic responses seen in these 2 cases suggest that denosumab may represent a viable alternative or adjunctive procedure to eliminate or decrease the extent of surgical intervention and morbidity in the treatment of CGCG. Future prospective studies with a larger sample would provide more comprehensive information about the long-term effects and possible adverse side effects of treating CGCG of the jaws with denosumab. In recent years, the treatment of central giant cell granuloma (CGCG) has become focused on the inhibition of osteoclast differentiation and proliferation. Medications that were developed for the treatment of giant cell tumor of bone and bone resorption from metastatic skeletal disease have shown some success in the treatment of CGCG. The present report describes 2 cases of CGCG of the mandible that were treated effectively with subcutaneous denosumab. Two cases of histologically diagnosed CGCG of the mandible were treated with monthly subcutaneous injections of denosumab 120 mg primarily or after intralesional corticosteroid therapy. Clinical and radiographic follow-ups were recorded over a period of 24 months (case 1) and 15 months (case 2). In the 2 cases, progressive radiodensity and osseous regeneration were noted 4 to 6 months after denosumab therapy was initiated. A decrease in lesion size and improvement in bone contour and facial symmetry were seen in the 2 cases. The major radiographic, clinical, and histologic responses seen in these 2 cases suggest that denosumab may represent a viable alternative or adjunctive procedure to eliminate or decrease the extent of surgical intervention and morbidity in the treatment of CGCG. Future prospective studies with a larger sample would provide more comprehensive information about the long-term effects and possible adverse side effects of treating CGCG of the jaws with denosumab." @default.
• W2069442595 created "2016-06-24" @default.
• W2069442595 creator A5020745459 @default.
• W2069442595 creator A5021801156 @default.
• W2069442595 creator A5041560890 @default.
• W2069442595 creator A5060335134 @default.
• W2069442595 date "2014-12-01" @default.
• W2069442595 modified "2023-10-16" @default.
• W2069442595 title "Management of Central Giant Cell Granuloma With Subcutaneous Denosumab Therapy" @default.
• W2069442595 cites W1506243110 @default.
• W2069442595 cites W1572906866 @default.
• W2069442595 cites W1964141893 @default.
• W2069442595 cites W1980242186 @default.
• W2069442595 cites W1989053431 @default.
• W2069442595 cites W1992804470 @default.
• W2069442595 cites W1994779874 @default.
• W2069442595 cites W2002731376 @default.
• W2069442595 cites W2005694811 @default.
• W2069442595 cites W2014608686 @default.
• W2069442595 cites W2020448033 @default.
• W2069442595 cites W2028541032 @default.
• W2069442595 cites W2038321403 @default.
• W2069442595 cites W2039072852 @default.
• W2069442595 cites W2045165033 @default.
• W2069442595 cites W2046919639 @default.
• W2069442595 cites W2048719426 @default.
• W2069442595 cites W2048964656 @default.
• W2069442595 cites W2049548696 @default.
• W2069442595 cites W2052946642 @default.
• W2069442595 cites W2060480525 @default.
• W2069442595 cites W2065823483 @default.
• W2069442595 cites W2070890020 @default.
• W2069442595 cites W2079049237 @default.
• W2069442595 cites W2082410913 @default.
• W2069442595 cites W2085167953 @default.
• W2069442595 cites W2087574295 @default.
• W2069442595 cites W2090423758 @default.
• W2069442595 cites W2093956992 @default.
• W2069442595 cites W2097855732 @default.
• W2069442595 cites W2107312399 @default.
• W2069442595 cites W2108700225 @default.
• W2069442595 cites W2113898373 @default.
• W2069442595 cites W2130998370 @default.
• W2069442595 cites W2139860898 @default.
• W2069442595 cites W2141070796 @default.
• W2069442595 cites W2143508491 @default.
• W2069442595 cites W2149775776 @default.
• W2069442595 cites W2150904792 @default.
• W2069442595 cites W2158489452 @default.
• W2069442595 cites W2158999082 @default.
• W2069442595 cites W2159152276 @default.
• W2069442595 cites W2163058169 @default.
• W2069442595 cites W2164211886 @default.
• W2069442595 cites W2165011173 @default.
• W2069442595 cites W2168689724 @default.
• W2069442595 cites W2170527535 @default.
• W2069442595 cites W2332927548 @default.
• W2069442595 cites W3128388187 @default.
• W2069442595 cites W4294956436 @default.
• W2069442595 cites W4371613865 @default.
• W2069442595 doi "https://doi.org/10.1016/j.joms.2014.06.456" @default.
• W2069442595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25262402" @default.
• W2069442595 hasPublicationYear "2014" @default.
• W2069442595 type Work @default.
• W2069442595 sameAs 2069442595 @default.
• W2069442595 citedByCount "51" @default.
• W2069442595 countsByYear W20694425952015 @default.
• W2069442595 countsByYear W20694425952016 @default.
• W2069442595 countsByYear W20694425952017 @default.
• W2069442595 countsByYear W20694425952018 @default.
• W2069442595 countsByYear W20694425952019 @default.
• W2069442595 countsByYear W20694425952020 @default.
• W2069442595 countsByYear W20694425952021 @default.
• W2069442595 countsByYear W20694425952022 @default.
• W2069442595 countsByYear W20694425952023 @default.
• W2069442595 crossrefType "journal-article" @default.
• W2069442595 hasAuthorship W2069442595A5020745459 @default.
• W2069442595 hasAuthorship W2069442595A5021801156 @default.
• W2069442595 hasAuthorship W2069442595A5041560890 @default.
• W2069442595 hasAuthorship W2069442595A5060335134 @default.
• W2069442595 hasConcept C126322002 @default.
• W2069442595 hasConcept C141071460 @default.
• W2069442595 hasConcept C142724271 @default.
• W2069442595 hasConcept C157369684 @default.
• W2069442595 hasConcept C170493617 @default.
• W2069442595 hasConcept C197934379 @default.
• W2069442595 hasConcept C2776033226 @default.
• W2069442595 hasConcept C2776286101 @default.
• W2069442595 hasConcept C2776541429 @default.
• W2069442595 hasConcept C2779767645 @default.
• W2069442595 hasConcept C2780134995 @default.
• W2069442595 hasConcept C2781156865 @default.
• W2069442595 hasConcept C59822182 @default.
• W2069442595 hasConcept C673006 @default.
• W2069442595 hasConcept C71924100 @default.
• W2069442595 hasConcept C77076574 @default.
• W2069442595 hasConcept C86803240 @default.
• W2069442595 hasConceptScore W2069442595C126322002 @default.

• next