Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069450123> ?p ?o ?g. }
- W2069450123 endingPage "5092" @default.
- W2069450123 startingPage "5080" @default.
- W2069450123 abstract "Measles virus (MV) is one of the most infectious pathogens known. Despite the existence of a vaccine, over 500 000 deaths/year result from MV or associated complications. Anti-measles compounds could conceivably reverse these statistics. Previously, we described a homology model of the MV fusion protein trimer and a putative binding site near the head−neck region. The resulting model permitted the identification of two nonpeptidic entry inhibitors. Here, we present the design, synthesis, and bioevaluation of several series of fusion inhibitors and describe their structure-activity relationships (SAR). Five simply substituted anilides show low-μM blockade of the MV, one of which (AS-48) exhibits IC50 = 0.6−3.0 μM across a panel of wild-type MV strains found in the field. Molecular field topology analysis (MFTA), a 2D QSAR approach based on local molecular properties (atomic charges, hydrogen-bonding capacity and local lipophilicity), applied to the anilide series suggests structural modifications to improve potency." @default.
- W2069450123 created "2016-06-24" @default.
- W2069450123 creator A5017740111 @default.
- W2069450123 creator A5023927261 @default.
- W2069450123 creator A5032077625 @default.
- W2069450123 creator A5038543487 @default.
- W2069450123 creator A5041063201 @default.
- W2069450123 creator A5046121798 @default.
- W2069450123 creator A5050532377 @default.
- W2069450123 creator A5060194950 @default.
- W2069450123 creator A5064720448 @default.
- W2069450123 creator A5070703755 @default.
- W2069450123 creator A5071096198 @default.
- W2069450123 creator A5083556586 @default.
- W2069450123 creator A5085576329 @default.
- W2069450123 date "2006-08-01" @default.
- W2069450123 modified "2023-10-17" @default.
- W2069450123 title "Nonpeptide Inhibitors of Measles Virus Entry" @default.
- W2069450123 cites W1585400823 @default.
- W2069450123 cites W1591890160 @default.
- W2069450123 cites W1845094941 @default.
- W2069450123 cites W1855831927 @default.
- W2069450123 cites W2006610286 @default.
- W2069450123 cites W2012735516 @default.
- W2069450123 cites W2013397574 @default.
- W2069450123 cites W2016683905 @default.
- W2069450123 cites W2022891312 @default.
- W2069450123 cites W2032954528 @default.
- W2069450123 cites W2033757712 @default.
- W2069450123 cites W2042288895 @default.
- W2069450123 cites W2043912768 @default.
- W2069450123 cites W2044108238 @default.
- W2069450123 cites W2046825469 @default.
- W2069450123 cites W2063831812 @default.
- W2069450123 cites W2066114387 @default.
- W2069450123 cites W2071172219 @default.
- W2069450123 cites W2081977505 @default.
- W2069450123 cites W2090643713 @default.
- W2069450123 cites W2091032640 @default.
- W2069450123 cites W2092489891 @default.
- W2069450123 cites W2108508060 @default.
- W2069450123 cites W2112129496 @default.
- W2069450123 cites W2112131257 @default.
- W2069450123 cites W2118316865 @default.
- W2069450123 cites W2120434154 @default.
- W2069450123 cites W2135232652 @default.
- W2069450123 cites W2154625168 @default.
- W2069450123 cites W2182660457 @default.
- W2069450123 doi "https://doi.org/10.1021/jm0602559" @default.
- W2069450123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16913698" @default.
- W2069450123 hasPublicationYear "2006" @default.
- W2069450123 type Work @default.
- W2069450123 sameAs 2069450123 @default.
- W2069450123 citedByCount "59" @default.
- W2069450123 countsByYear W20694501232012 @default.
- W2069450123 countsByYear W20694501232013 @default.
- W2069450123 countsByYear W20694501232014 @default.
- W2069450123 countsByYear W20694501232015 @default.
- W2069450123 countsByYear W20694501232016 @default.
- W2069450123 countsByYear W20694501232017 @default.
- W2069450123 countsByYear W20694501232018 @default.
- W2069450123 countsByYear W20694501232019 @default.
- W2069450123 countsByYear W20694501232020 @default.
- W2069450123 countsByYear W20694501232021 @default.
- W2069450123 countsByYear W20694501232022 @default.
- W2069450123 countsByYear W20694501232023 @default.
- W2069450123 crossrefType "journal-article" @default.
- W2069450123 hasAuthorship W2069450123A5017740111 @default.
- W2069450123 hasAuthorship W2069450123A5023927261 @default.
- W2069450123 hasAuthorship W2069450123A5032077625 @default.
- W2069450123 hasAuthorship W2069450123A5038543487 @default.
- W2069450123 hasAuthorship W2069450123A5041063201 @default.
- W2069450123 hasAuthorship W2069450123A5046121798 @default.
- W2069450123 hasAuthorship W2069450123A5050532377 @default.
- W2069450123 hasAuthorship W2069450123A5060194950 @default.
- W2069450123 hasAuthorship W2069450123A5064720448 @default.
- W2069450123 hasAuthorship W2069450123A5070703755 @default.
- W2069450123 hasAuthorship W2069450123A5071096198 @default.
- W2069450123 hasAuthorship W2069450123A5083556586 @default.
- W2069450123 hasAuthorship W2069450123A5085576329 @default.
- W2069450123 hasConcept C112887158 @default.
- W2069450123 hasConcept C159047783 @default.
- W2069450123 hasConcept C164126121 @default.
- W2069450123 hasConcept C169627665 @default.
- W2069450123 hasConcept C178790620 @default.
- W2069450123 hasConcept C178910836 @default.
- W2069450123 hasConcept C181199279 @default.
- W2069450123 hasConcept C185592680 @default.
- W2069450123 hasConcept C201399114 @default.
- W2069450123 hasConcept C22070199 @default.
- W2069450123 hasConcept C2776096392 @default.
- W2069450123 hasConcept C2776403692 @default.
- W2069450123 hasConcept C2776438120 @default.
- W2069450123 hasConcept C2778199166 @default.
- W2069450123 hasConcept C2779546866 @default.
- W2069450123 hasConcept C32909587 @default.
- W2069450123 hasConcept C55493867 @default.
- W2069450123 hasConcept C70721500 @default.