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- W2069450151 abstract "We use micropatterning and strain engineering to encapsulate single living mammalian cells into transparent tubular architectures consisting of three-dimensional (3D) rolled-up nanomembranes. By using optical microscopy, we demonstrate that these structures are suitable for the scrutiny of cellular dynamics within confined 3D-microenvironments. We show that spatial confinement of mitotic mammalian cells inside tubular architectures can perturb metaphase plate formation, delay mitotic progression, and cause chromosomal instability in both a transformed and nontransformed human cell line. These findings could provide important clues into how spatial constraints dictate cellular behavior and function." @default.
- W2069450151 created "2016-06-24" @default.
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- W2069450151 date "2014-03-10" @default.
- W2069450151 modified "2023-10-09" @default.
- W2069450151 title "Rolled-up Functionalized Nanomembranes as Three-Dimensional Cavities for Single Cell Studies" @default.
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- W2069450151 doi "https://doi.org/10.1021/nl4042565" @default.
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