FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069458082> ?p ?o ?g. }

• W2069458082 endingPage "530" @default.
• W2069458082 startingPage "520" @default.
• W2069458082 abstract "Background Although accumulating evidence shows that mesenchymal stem cells (MSC) are a promising cell source for articular cartilage repair, the fate of transplanted MSC has not been extensively studied. Methods To monitor their persistence and differentiation, we labeled uninduced MSC with a fluorescent dye, PKH26, and transplanted them, in a poly-glycolic-acid scaffold, to full-thickness defects made in the weight-bearing area of rabbit femoral trochleae with hyaluronate sheets. The fate of the labeled cells was monitored for up to 8 weeks. Results Two weeks after transplantation, immature cartilage containing collagen type II had formed. By 8 weeks, this cartilage had thinned and immunolabeling for collagen type II gradually disappeared from the basal region, which became positive for collagen type I. Most chondrocytes within the regenerated cartilage were PKH26-positive and, therefore, derived from transplanted MSC, whereas osteoblasts within the regenerated bone were a mixture of donor- and host-derived cells. The thickness of the cartilage became thinner up to 8 weeks and then remained stable up to 42 weeks after surgery. Discussion These results showed that uninduced MSC were able to survive osteochondral defects and differentiated according to the environment, making a major contribution to initial cartilage formation and a partial contribution to bone regeneration. Although accumulating evidence shows that mesenchymal stem cells (MSC) are a promising cell source for articular cartilage repair, the fate of transplanted MSC has not been extensively studied. To monitor their persistence and differentiation, we labeled uninduced MSC with a fluorescent dye, PKH26, and transplanted them, in a poly-glycolic-acid scaffold, to full-thickness defects made in the weight-bearing area of rabbit femoral trochleae with hyaluronate sheets. The fate of the labeled cells was monitored for up to 8 weeks. Two weeks after transplantation, immature cartilage containing collagen type II had formed. By 8 weeks, this cartilage had thinned and immunolabeling for collagen type II gradually disappeared from the basal region, which became positive for collagen type I. Most chondrocytes within the regenerated cartilage were PKH26-positive and, therefore, derived from transplanted MSC, whereas osteoblasts within the regenerated bone were a mixture of donor- and host-derived cells. The thickness of the cartilage became thinner up to 8 weeks and then remained stable up to 42 weeks after surgery. These results showed that uninduced MSC were able to survive osteochondral defects and differentiated according to the environment, making a major contribution to initial cartilage formation and a partial contribution to bone regeneration." @default.
• W2069458082 created "2016-06-24" @default.
• W2069458082 creator A5000020735 @default.
• W2069458082 creator A5014283278 @default.
• W2069458082 creator A5029341850 @default.
• W2069458082 creator A5041987340 @default.
• W2069458082 creator A5076974173 @default.
• W2069458082 date "2005-01-01" @default.
• W2069458082 modified "2023-10-11" @default.
• W2069458082 title "Differentiation of transplanted mesenchymal stem cells in a large osteochondral defect in rabbit" @default.
• W2069458082 cites W1522229466 @default.
• W2069458082 cites W1946911025 @default.
• W2069458082 cites W1967474304 @default.
• W2069458082 cites W1982115945 @default.
• W2069458082 cites W1982534962 @default.
• W2069458082 cites W1986867932 @default.
• W2069458082 cites W1988592246 @default.
• W2069458082 cites W2010137939 @default.
• W2069458082 cites W2011114620 @default.
• W2069458082 cites W2011405028 @default.
• W2069458082 cites W2031951869 @default.
• W2069458082 cites W2064407507 @default.
• W2069458082 cites W2074473202 @default.
• W2069458082 cites W2125661032 @default.
• W2069458082 cites W2144268541 @default.
• W2069458082 cites W2146389343 @default.
• W2069458082 cites W2151273918 @default.
• W2069458082 cites W2152174008 @default.
• W2069458082 cites W2155704507 @default.
• W2069458082 cites W33535528 @default.
• W2069458082 cites W4296746237 @default.
• W2069458082 cites W76337861 @default.
• W2069458082 doi "https://doi.org/10.1080/14653240500361350" @default.
• W2069458082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16306014" @default.
• W2069458082 hasPublicationYear "2005" @default.
• W2069458082 type Work @default.
• W2069458082 sameAs 2069458082 @default.
• W2069458082 citedByCount "77" @default.
• W2069458082 countsByYear W20694580822012 @default.
• W2069458082 countsByYear W20694580822013 @default.
• W2069458082 countsByYear W20694580822014 @default.
• W2069458082 countsByYear W20694580822015 @default.
• W2069458082 countsByYear W20694580822016 @default.
• W2069458082 countsByYear W20694580822017 @default.
• W2069458082 countsByYear W20694580822018 @default.
• W2069458082 countsByYear W20694580822019 @default.
• W2069458082 countsByYear W20694580822020 @default.
• W2069458082 countsByYear W20694580822021 @default.
• W2069458082 countsByYear W20694580822023 @default.
• W2069458082 crossrefType "journal-article" @default.
• W2069458082 hasAuthorship W2069458082A5000020735 @default.
• W2069458082 hasAuthorship W2069458082A5014283278 @default.
• W2069458082 hasAuthorship W2069458082A5029341850 @default.
• W2069458082 hasAuthorship W2069458082A5041987340 @default.
• W2069458082 hasAuthorship W2069458082A5076974173 @default.
• W2069458082 hasConcept C104317684 @default.
• W2069458082 hasConcept C105702510 @default.
• W2069458082 hasConcept C13685319 @default.
• W2069458082 hasConcept C141071460 @default.
• W2069458082 hasConcept C142724271 @default.
• W2069458082 hasConcept C148738053 @default.
• W2069458082 hasConcept C171056886 @default.
• W2069458082 hasConcept C185592680 @default.
• W2069458082 hasConcept C198826908 @default.
• W2069458082 hasConcept C204232928 @default.
• W2069458082 hasConcept C20875687 @default.
• W2069458082 hasConcept C2777877921 @default.
• W2069458082 hasConcept C2780550940 @default.
• W2069458082 hasConcept C2781013607 @default.
• W2069458082 hasConcept C28328180 @default.
• W2069458082 hasConcept C2911091166 @default.
• W2069458082 hasConcept C35496256 @default.
• W2069458082 hasConcept C55493867 @default.
• W2069458082 hasConcept C71924100 @default.
• W2069458082 hasConcept C86803240 @default.
• W2069458082 hasConcept C95444343 @default.
• W2069458082 hasConceptScore W2069458082C104317684 @default.
• W2069458082 hasConceptScore W2069458082C105702510 @default.
• W2069458082 hasConceptScore W2069458082C13685319 @default.
• W2069458082 hasConceptScore W2069458082C141071460 @default.
• W2069458082 hasConceptScore W2069458082C142724271 @default.
• W2069458082 hasConceptScore W2069458082C148738053 @default.
• W2069458082 hasConceptScore W2069458082C171056886 @default.
• W2069458082 hasConceptScore W2069458082C185592680 @default.
• W2069458082 hasConceptScore W2069458082C198826908 @default.
• W2069458082 hasConceptScore W2069458082C204232928 @default.
• W2069458082 hasConceptScore W2069458082C20875687 @default.
• W2069458082 hasConceptScore W2069458082C2777877921 @default.
• W2069458082 hasConceptScore W2069458082C2780550940 @default.
• W2069458082 hasConceptScore W2069458082C2781013607 @default.
• W2069458082 hasConceptScore W2069458082C28328180 @default.
• W2069458082 hasConceptScore W2069458082C2911091166 @default.
• W2069458082 hasConceptScore W2069458082C35496256 @default.
• W2069458082 hasConceptScore W2069458082C55493867 @default.
• W2069458082 hasConceptScore W2069458082C71924100 @default.
• W2069458082 hasConceptScore W2069458082C86803240 @default.
• W2069458082 hasConceptScore W2069458082C95444343 @default.
• W2069458082 hasIssue "6" @default.

• next