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- W2069462480 abstract "Penicillin V acylase (PVA) used in the production of 6-aminopenicillanic acid (6-APA) and 7-aminodesacetoxycephalosporanic acid (7-ADCA) is produced by a wide range of microorganisms. Both traditional mutagenic and modern genetic engineering techniques are applied to isolate the strains producing large amounts of PVA. Productivity as high as 3,200 U g−1 dry cell weight is achieved. Comparison of the physicochemical properties of purified enzyme preparations indicate a wide variation; however, in general the PVAs are specific for phenoxyacetyl amides of beta-lactam molecules and very few enzymes hydrolyze other phenoxyacetyl derivatives. Both immobilized enzyme and cell preparations are developed for production of 6-APA and 7-ADCA. The advantages of PVA in the production of 6-APA are discussed." @default.
- W2069462480 created "2016-06-24" @default.
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- W2069462480 date "1997-05-01" @default.
- W2069462480 modified "2023-10-10" @default.
- W2069462480 title "Penicillin V acylase: Its potential in the production of 6-aminopenicillanic acid" @default.
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- W2069462480 doi "https://doi.org/10.1016/s0141-0229(96)00176-7" @default.
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